Functional and structural insights into the multi-step activation and catalytic mechanism of bacterial ExoY nucleotidyl cyclase toxins bound to actin-profilin

• Magda Teixeira Nunes,

  Roles Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

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• Pascal Retailleau,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Université Paris Saclay, CNRS, Institut de Chimie des Substances Naturelles, Gif-sur-Yvette, France

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• Dorothée Raoux-Barbot,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Unité de Biochimie des Interactions macromoléculaires, Département de Biologie Structurale et Chimie, Paris, France

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• Martine Comisso,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

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• Anani Amegan Missinou,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

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• Christophe Velours,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Current address: Fundamental Microbiology and Pathogenicity Laboratory, UMR 5234 CNRS-University of Bordeaux, SFR TransBioMed, Bordeaux, France

  Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

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• Stéphane Plancqueel,

  Roles Investigation

  Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

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• Daniel Ladant,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Unité de Biochimie des Interactions macromoléculaires, Département de Biologie Structurale et Chimie, Paris, France

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• Undine Mechold,

  Roles Formal analysis, Funding acquisition, Investigation, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR 3528, Unité de Biochimie des Interactions macromoléculaires, Département de Biologie Structurale et Chimie, Paris, France

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• Louis Renault

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: louis.renault@i2bc.paris-saclay.fr

  Affiliation Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France

  https://orcid.org/0000-0003-1722-074X

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