Immunotherapy of cytomegalovirus infection by low-dose adoptive transfer of antiviral CD8 T cells relies on substantial post-transfer expansion of central memory cells but not effector-memory cells

• Rafaela Holtappels ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: r.holtappels@uni-mainz.de

  Affiliations Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

  https://orcid.org/0000-0001-5767-5111

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• Sara Becker ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

  ¶‡ SB and SH are joint second authors of this work. NAL and MJR are joint senior authors of this work.

  Affiliations Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany

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• Sara Hamdan ,

  Roles Formal analysis, Investigation, Methodology

  ¶‡ SB and SH are joint second authors of this work. NAL and MJR are joint senior authors of this work.

  Affiliation Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

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• Kirsten Freitag,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

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• Jürgen Podlech,

  Roles Data curation, Investigation, Methodology, Supervision

  Affiliation Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

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• Niels A. Lemmermann ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Validation, Writing – review & editing

  ¶‡ SB and SH are joint second authors of this work. NAL and MJR are joint senior authors of this work.

  Affiliations Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Institute of Virology, Medical Faculty, University of Bonn, Bonn, Germany

  https://orcid.org/0000-0001-9190-6497

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• Matthias J. Reddehase

  Roles Conceptualization, Funding acquisition, Writing – original draft

  ¶‡ SB and SH are joint second authors of this work. NAL and MJR are joint senior authors of this work.

  Affiliations Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany

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