Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing

• Ya Yan ,

  Contributed equally to this work with: Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Lei Wu ,

  Contributed equally to this work with: Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Ye Yuan ,

  Contributed equally to this work with: Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Haiwei Wang ,

  Contributed equally to this work with: Ya Yan, Lei Wu, Ye Yuan, Haiwei Wang

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation

  Affiliation State Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Hongyan Yin,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Minjie Li,

  Roles Formal analysis, Software

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Lvye Chai,

  Roles Formal analysis, Software

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

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• Ruiying Liang,

  Roles Resources

  Affiliation Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China

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• Yanjie Liu,

  Roles Resources

  Affiliation College of Animal Sciences, Shanxi Agricultural University, Jinzhong, China

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• Dongming Zhao,

  Roles Resources

  Affiliation State Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

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• Junji Xing,

  Roles Writing – review & editing

  Affiliations Department of Surgery and Immunobiology and Transplant Science Center, Houston Methodist Research Institute, Houston Methodist, Houston, Texas, United States of America, Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston Methodist, Houston, Texas, United States of America

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• Pingwei Li,

  Roles Writing – review & editing

  Affiliation Department of Biochemistry and Biophysics, Texas A&M University, College Station, Texas, United States of America

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• Xin Li

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft

  * E-mail: xinli2021@cau.edu.cn

  Affiliations National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China, Key Laboratory of Animal Epidemiology of the Ministry of Agriculture and Rural Affairs, College of Veterinary Medicine, China Agricultural University, Beijing, China

  https://orcid.org/0000-0003-1636-8910

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