Multiplex interrogation of the NK cell signalome reveals global downregulation of CD16 signaling during lentivirus infection through an IL-18/ADAM17-dependent mechanism

• Sho Sugawara,

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• Brady Hueber,

  Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• Griffin Woolley,

  Roles Data curation, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• Karen Terry,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• Kyle Kroll,

  Roles Data curation, Formal analysis, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• Cordelia Manickam,

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• Daniel R. Ram,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Lishomwa C. Ndhlovu,

  Roles Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York City, New York, United States of America

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• Paul Goepfert,

  Roles Resources, Writing – original draft, Writing – review & editing

  Affiliation University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Stephanie Jost,

  Roles Conceptualization, Resources, Writing – original draft, Writing – review & editing

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America

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• R. Keith Reeves

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: keith.reeves@duke.edu

  Affiliations Division of Innate and Comparative Immunology, Center for Human Systems Immunology, Duke University School of Medicine, Durham, North Carolina, United States of America, Department of Surgery, Duke University, Durham, North Carolina, United States of America, Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

  https://orcid.org/0000-0003-3157-2557

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