Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Shiromani Jayawardhana; Alexander I. Ward; Amanda F. Francisco; Michael D. Lewis; Martin C. Taylor; John M. Kelly; Francisco Olmo

doi:10.1371/journal.ppat.1011627

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Open Access

Peer-reviewed

Research Article

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Shiromani Jayawardhana,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Alexander I. Ward,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Current address: Institute of Immunity and Transplantation, University College London, London, UK

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Amanda F. Francisco,

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Michael D. Lewis,

Roles Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Martin C. Taylor,

Roles Conceptualization, Formal analysis, Supervision, Writing – review & editing

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
John M. Kelly ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: john.kelly@lshtm.ac.uk (JMK); francisco.olmo@lshtm.ac.uk (FO)

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom

https://orcid.org/0000-0003-4305-5258

⨯
Francisco Olmo

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

* E-mail: john.kelly@lshtm.ac.uk (JMK); francisco.olmo@lshtm.ac.uk (FO)

Affiliation Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Shiromani Jayawardhana,
Alexander I. Ward,
Amanda F. Francisco,
Michael D. Lewis,
Martin C. Taylor,
John M. Kelly,
Francisco Olmo

Published: November 13, 2023
https://doi.org/10.1371/journal.ppat.1011627

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Parasitic diseases
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Amastigotes
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Trypanosoma cruzi
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DNA damage
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