LGP2 directly interacts with flavivirus NS5 RNA-dependent RNA polymerase and downregulates its pre-elongation activities

• Zhongyuan Tan ,

  Contributed equally to this work with: Zhongyuan Tan, Jiqin Wu

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation The Joint Laboratory for Translational Precision Medicine, a. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China and b. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Jiqin Wu ,

  Contributed equally to this work with: Zhongyuan Tan, Jiqin Wu

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Li Huang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation The Joint Laboratory for Translational Precision Medicine, a. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China and b. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Ting Wang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, NHC Key Laboratory of Respiratory Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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• Zhenhua Zheng,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Jianhui Zhang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation The Joint Laboratory for Translational Precision Medicine, a. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China and b. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Xianliang Ke,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Yuan Zhang,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Yan Liu,

  Roles Formal analysis, Methodology, Project administration, Writing – review & editing

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Hanzhong Wang ,

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: wanghz@wh.iov.cn (HW); golou6354@163.com (JT); gongpeng@wh.iov.cn (PG)

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Jianping Tao ,

  Roles Conceptualization, Data curation, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: wanghz@wh.iov.cn (HW); golou6354@163.com (JT); gongpeng@wh.iov.cn (PG)

  Affiliation The Joint Laboratory for Translational Precision Medicine, a. Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China and b. Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  ⨯
• Peng Gong

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: wanghz@wh.iov.cn (HW); golou6354@163.com (JT); gongpeng@wh.iov.cn (PG)

  Affiliation Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China

  https://orcid.org/0000-0002-8264-7523

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