A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo

• Taha Y. Taha ,

  Contributed equally to this work with: Taha Y. Taha, Rahul K. Suryawanshi, Irene P. Chen, Galen J. Correy

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

  https://orcid.org/0000-0002-7344-7490

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• Rahul K. Suryawanshi ,

  Contributed equally to this work with: Taha Y. Taha, Rahul K. Suryawanshi, Irene P. Chen, Galen J. Correy

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliations Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

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• Irene P. Chen ,

  Contributed equally to this work with: Taha Y. Taha, Rahul K. Suryawanshi, Irene P. Chen, Galen J. Correy

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, Department of Medicine, University of California, San Francisco, California, United States of America

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• Galen J. Correy ,

  Contributed equally to this work with: Taha Y. Taha, Rahul K. Suryawanshi, Irene P. Chen, Galen J. Correy

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

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• Maria McCavitt-Malvido,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America

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• Patrick C. O’Leary,

  Roles Data curation, Investigation, Methodology

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America

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• Manasi P. Jogalekar,

  Roles Investigation, Methodology

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America

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• Morgan E. Diolaiti,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America

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• Gabriella R. Kimmerly,

  Roles Investigation, Methodology

  Affiliation Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America

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• Chia-Lin Tsou,

  Roles Investigation, Methodology

  Affiliation Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America

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• Ronnie Gascon,

  Roles Investigation, Methodology

  Affiliation Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America

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• Mauricio Montano,

  Roles Investigation, Methodology

  Affiliation Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America

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• Luis Martinez-Sobrido,

  Roles Writing – review & editing

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

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• Nevan J. Krogan,

  Roles Funding acquisition

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, Gladstone Institute of Data Science and Biotechnology, Gladstone Institutes, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI), University of California, San Francisco, California, United States of America, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California, United States of America

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• Alan Ashworth ,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: alan.ashworth@ucsf.edu (AA); jfraser@fraserlab.com (JSF); melanie.ott@gladstone.ucsf.edu (MO)

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States of America

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• James S. Fraser ,

  Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: alan.ashworth@ucsf.edu (AA); jfraser@fraserlab.com (JSF); melanie.ott@gladstone.ucsf.edu (MO)

  Affiliations Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

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•  [ ... ],
• Melanie Ott

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: alan.ashworth@ucsf.edu (AA); jfraser@fraserlab.com (JSF); melanie.ott@gladstone.ucsf.edu (MO)

  Affiliations Gladstone Institute of Virology, Gladstone Institutes, San Francisco, California, United States of America, Quantitative Biosciences Institute (QBI) COVID-19 Research Group (QCRG), San Francisco, California, United States of America, Department of Medicine, University of California, San Francisco, California, United States of America, Chan Zuckerberg Biohub–San Francisco, San Francisco, California, United States of America

  https://orcid.org/0000-0002-5697-1274

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