A yeast-based system to study SARS-CoV-2 M^pro structure and to identify nirmatrelvir resistant mutations

• Jin Ou,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Biology, School of Arts and Sciences, The Catholic University of America, Washington, Washington DC, United States of America

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• Eric M. Lewandowski,

  Roles Investigation

  Affiliation Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America

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• Yanmei Hu,

  Roles Investigation

  Affiliation Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America

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• Austin A. Lipinski,

  Roles Investigation

  Affiliation Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America

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• Ali Aljasser,

  Roles Investigation

  Affiliation Department of Biology, School of Arts and Sciences, The Catholic University of America, Washington, Washington DC, United States of America

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• Mariliz Colon-Ascanio,

  Roles Investigation

  Affiliation Department of Biology, School of Arts and Sciences, The Catholic University of America, Washington, Washington DC, United States of America

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• Ryan T. Morgan,

  Roles Investigation

  Affiliation Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America

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• Lian M. C. Jacobs,

  Roles Investigation

  Affiliations Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America, Drug Discovery Department, Moffit Cancer Center, Tampa, Florida, United States of America

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• Xiujun Zhang,

  Roles Investigation

  Affiliation Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America

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• Melissa J. Bikowitz,

  Roles Investigation

  Affiliation Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America

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• Paul R. Langlais,

  Roles Investigation

  Affiliation Department of Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America

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• Haozhou Tan,

  Roles Investigation

  Affiliation Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America

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• Jun Wang ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: junwang@pharmacy.rutgers.edu (JW); ychen1@usf.edu (YC); choy@cua.edu (JSC)

  Affiliation Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey, Piscataway, New Jersey, United States of America

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• Yu Chen ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: junwang@pharmacy.rutgers.edu (JW); ychen1@usf.edu (YC); choy@cua.edu (JSC)

  Affiliation Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, United States of America

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• John S. Choy

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: junwang@pharmacy.rutgers.edu (JW); ychen1@usf.edu (YC); choy@cua.edu (JSC)

  Affiliation Department of Biology, School of Arts and Sciences, The Catholic University of America, Washington, Washington DC, United States of America

  https://orcid.org/0000-0001-9196-3280

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