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Open Access
Peer-reviewed
Research Article
NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG
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Padmapriya Sekar,
Roles Investigation, Writing – original draft, Writing – review & editing
Current address: TeraImmune, Germantown, Maryland, United States of America
Affiliation Molecular and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Sumati Rajagopalan ,
Roles Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing
* E-mail: srajagop@niaid.nih.gov (SR); eLong@nih.gov (EOL)
Affiliation Molecular and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Estela Shabani,
Roles Investigation
Affiliation Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America
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Usheer Kanjee,
Roles Investigation
Affiliation Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America
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Marc A. Schureck,
Roles Investigation
Current address: Department of Biology, Loxo Oncology at Lilly, San Diego, California, United States of America
Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Gunjan Arora,
Roles Conceptualization, Investigation
Current address: Laboratory of Host-Pathogen Dynamics, National Heart Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America
Affiliation Molecular and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Mary E. Peterson,
Roles Investigation
Affiliations Molecular and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America, Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Boubacar Traore,
Roles Resources
Affiliation Malaria Research and Training Center, Mali International Center for Excellence in Research, University of Sciences, Techniques, and Technologies of Bamako, Bamako, Mali
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Peter D. Crompton,
Roles Resources
Affiliation Malaria Infection Biology and Immunity Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Manoj T. Duraisingh,
Roles Methodology, Resources
Affiliation Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America
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Sanjay A. Desai,
Roles Funding acquisition, Methodology, Supervision
Affiliation Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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Eric O. Long
Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing
* E-mail: srajagop@niaid.nih.gov (SR); eLong@nih.gov (EOL)
Affiliation Molecular and Cellular Immunology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
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NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG
- Padmapriya Sekar,
- Sumati Rajagopalan,
- Estela Shabani,
- Usheer Kanjee,
- Marc A. Schureck,
- Gunjan Arora,
- Mary E. Peterson,
- Boubacar Traore,
- Peter D. Crompton,
- Manoj T. Duraisingh
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- Published: November 8, 2023
- https://doi.org/10.1371/journal.ppat.1011585