SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

Chiara Aloise; Jelle G. Schipper; Arno van Vliet; Judith Oymans; Tim Donselaar; Daniel L. Hurdiss; Raoul J. de Groot; Frank J. M. van Kuppeveld

doi:10.1371/journal.ppat.1011582

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Open Access

Peer-reviewed

Research Article

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

Chiara Aloise,

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
⨯
Jelle G. Schipper,

Roles Conceptualization, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
⨯
Arno van Vliet,

Roles Investigation, Writing – review & editing

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
⨯
Judith Oymans,

Roles Investigation, Writing – review & editing

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
⨯
Tim Donselaar,

Roles Investigation, Writing – review & editing

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
⨯
Daniel L. Hurdiss,

Roles Formal analysis, Writing – review & editing

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
⨯
Raoul J. de Groot ,

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

* E-mail: R.J.deGroot@uu.nl (RJdG); F.J.M.vanKuppeveld@uu.nl (FJMvK)

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

https://orcid.org/0000-0002-2207-9472

⨯
Frank J. M. van Kuppeveld

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

* E-mail: R.J.deGroot@uu.nl (RJdG); F.J.M.vanKuppeveld@uu.nl (FJMvK)

Affiliation Virology Section, Division of Infectious Diseases and Immunology, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands

https://orcid.org/0000-0001-5800-749X

⨯

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

Chiara Aloise,
Jelle G. Schipper,
Arno van Vliet,
Judith Oymans,
Tim Donselaar,
Daniel L. Hurdiss,
Raoul J. de Groot,
Frank J. M. van Kuppeveld

Published: August 22, 2023
https://doi.org/10.1371/journal.ppat.1011582
See the preprint

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Coronaviruses
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RNA-binding proteins
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