Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface

Maitrayee Chatterjee; Liane Z. X. Huang; Anna Z. Mykytyn; Chunyan Wang; Mart M. Lamers; Bart Westendorp; Richard W. Wubbolts; Jos P. M. van Putten; Berend-Jan Bosch; Bart L. Haagmans; Karin Strijbis

doi:10.1371/journal.ppat.1011571

Loading metrics

Open Access

Peer-reviewed

Research Article

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface

Maitrayee Chatterjee ,

Contributed equally to this work with: Maitrayee Chatterjee, Liane Z. X. Huang, Anna Z. Mykytyn

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliation Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0002-7272-9242

⨯
Liane Z. X. Huang ,

Contributed equally to this work with: Maitrayee Chatterjee, Liane Z. X. Huang, Anna Z. Mykytyn

Roles Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization

Affiliation Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0002-3553-7874

⨯
Anna Z. Mykytyn ,

Contributed equally to this work with: Maitrayee Chatterjee, Liane Z. X. Huang, Anna Z. Mykytyn

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – review & editing

Affiliation Viroscience Department, Erasmus Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0001-7188-6871

⨯
Chunyan Wang,

Roles Investigation, Methodology, Resources

Current address: Department of Pathogenic Biology, School of Biomedical Sciences, Shandong University, Jinan, Shandong, P.R. China

Affiliation Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0002-4584-259X

⨯
Mart M. Lamers,

Roles Investigation, Methodology, Resources

Affiliation Viroscience Department, Erasmus Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0002-1431-4022

⨯
Bart Westendorp,

Roles Formal analysis, Investigation, Methodology, Visualization

Affiliation Department of Biomolecular Health Sciences, Division Cell Biology, Metabolism and Cancer, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0003-1043-3638

⨯
Richard W. Wubbolts,

Roles Investigation, Methodology, Visualization

Affiliation Viroscience Department, Erasmus Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0001-8661-7594

⨯
Jos P. M. van Putten,

Roles Resources, Supervision, Writing – review & editing

Affiliation Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0002-4126-8172

⨯
Berend-Jan Bosch,

Roles Methodology, Resources, Supervision

Affiliation Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0002-3864-232X

⨯
Bart L. Haagmans ,

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: b.haagmans@erasmusmc.nl (BLH); K.Strijbis@uu.nl (KS)

Affiliation Viroscience Department, Erasmus Medical Center, Rotterdam, The Netherlands

https://orcid.org/0000-0001-6221-2015

⨯
Karin Strijbis

Roles Conceptualization, Funding acquisition, Methodology, Supervision, Visualization, Writing – review & editing

* E-mail: b.haagmans@erasmusmc.nl (BLH); K.Strijbis@uu.nl (KS)

Affiliation Department of Biomolecular Health Sciences, Division Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

https://orcid.org/0000-0001-9167-7137

⨯

Glycosylated extracellular mucin domains protect against SARS-CoV-2 infection at the respiratory surface

Maitrayee Chatterjee,
Liane Z. X. Huang,
Anna Z. Mykytyn,
Chunyan Wang,
Mart M. Lamers,
Bart Westendorp,
Richard W. Wubbolts,
Jos P. M. van Putten,
Berend-Jan Bosch,
Bart L. Haagmans

Published: August 10, 2023
https://doi.org/10.1371/journal.ppat.1011571

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Mucin
Is the Subject Area "Mucin" applicable to this article?

Thanks for your feedback.
SARS CoV 2
Is the Subject Area "SARS CoV 2" applicable to this article?

Thanks for your feedback.
Respiratory infections
Is the Subject Area "Respiratory infections" applicable to this article?

Thanks for your feedback.
Sialic acids
Is the Subject Area "Sialic acids" applicable to this article?

Thanks for your feedback.
Confocal microscopy
Is the Subject Area "Confocal microscopy" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Cell binding
Is the Subject Area "Cell binding" applicable to this article?

Thanks for your feedback.
Immunofluorescence
Is the Subject Area "Immunofluorescence" applicable to this article?

Thanks for your feedback.