Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Stephen Adonai Leon-Icaza; Salimata Bagayoko; Romain Vergé; Nino Iakobachvili; Chloé Ferrand; Talip Aydogan; Célia Bernard; Angelique Sanchez Dafun; Marlène Murris-Espin; Julien Mazières; Pierre Jean Bordignon; Serge Mazères; Pascale Bernes-Lasserre; Victoria Ramé; Jean-Michel Lagarde; Julien Marcoux; Marie-Pierre Bousquet; Christian Chalut; Christophe Guilhot; Hans Clevers; Peter J. Peters; Virginie Molle; Geanncarlo Lugo-Villarino; Kaymeuang Cam; Laurence Berry; Etienne Meunier; Céline Cougoule

doi:10.1371/journal.ppat.1011559

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Open Access

Peer-reviewed

Research Article

Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Stephen Adonai Leon-Icaza,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
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Salimata Bagayoko,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Romain Vergé,

Roles Conceptualization, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Nino Iakobachvili,

Roles Conceptualization, Investigation, Methodology

Affiliation M4i Nanoscopy Division, Maastricht University, Maastricht, Netherlands
⨯
Chloé Ferrand,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Talip Aydogan,

Roles Conceptualization, Investigation, Methodology

Affiliation Laboratory of Pathogen Host Interactions (LPHI), Université Montpellier, CNRS, Montpellier, France
⨯
Célia Bernard,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Angelique Sanchez Dafun,

Roles Conceptualization, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Marlène Murris-Espin,

Roles Conceptualization, Methodology, Resources

Affiliations Service de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France, Centre de ressource et de compétence pour la mucoviscidose de l’adulte (CRCM adulte), CHU de Toulouse, Toulouse, France
⨯
Julien Mazières,

Roles Conceptualization, Methodology, Resources

Affiliation Service de Pneumologie, Hôpital Larrey, CHU de Toulouse, Toulouse, France
⨯
Pierre Jean Bordignon,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Serge Mazères,

Roles Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Pascale Bernes-Lasserre,

Roles Conceptualization, Methodology

Affiliation Imactiv-3D SAS, 1 Place Pierre POTIER, Toulouse, France
⨯
Victoria Ramé,

Roles Conceptualization, Methodology

Affiliation Imactiv-3D SAS, 1 Place Pierre POTIER, Toulouse, France
⨯
Jean-Michel Lagarde,

Roles Conceptualization, Methodology, Resources

Affiliation Imactiv-3D SAS, 1 Place Pierre POTIER, Toulouse, France
⨯
Julien Marcoux,

Roles Conceptualization, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Marie-Pierre Bousquet,

Roles Conceptualization, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Christian Chalut,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Christophe Guilhot,

Roles Resources

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Hans Clevers,

Roles Conceptualization, Methodology, Resources

Affiliation Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Center, Utrecht, Netherlands
⨯
Peter J. Peters,

Roles Conceptualization, Funding acquisition, Methodology, Resources

Affiliation M4i Nanoscopy Division, Maastricht University, Maastricht, Netherlands
⨯
Virginie Molle,

Roles Conceptualization, Funding acquisition, Methodology, Resources

Affiliation Laboratory of Pathogen Host Interactions (LPHI), Université Montpellier, CNRS, Montpellier, France
⨯
Geanncarlo Lugo-Villarino,

Roles Conceptualization, Funding acquisition, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Kaymeuang Cam,

Roles Conceptualization, Investigation, Methodology

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
Laurence Berry,

Roles Conceptualization, Funding acquisition, Methodology, Resources

Affiliation Laboratory of Pathogen Host Interactions (LPHI), Université Montpellier, CNRS, Montpellier, France
⨯
Etienne Meunier,

Roles Conceptualization, Funding acquisition, Methodology, Resources

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France
⨯
[ ... ],
Céline Cougoule

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources

* E-mail: Celine.Cougoule@ipbs.fr

Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III–Paul Sabatier (UPS), Toulouse, France

https://orcid.org/0000-0002-6795-5448

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Druggable redox pathways against Mycobacterium abscessus in cystic fibrosis patient-derived airway organoids

Stephen Adonai Leon-Icaza,
Salimata Bagayoko,
Romain Vergé,
Nino Iakobachvili,
Chloé Ferrand,
Talip Aydogan,
Célia Bernard,
Angelique Sanchez Dafun,
Marlène Murris-Espin,
Julien Mazières

Published: August 24, 2023
https://doi.org/10.1371/journal.ppat.1011559

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Oxidative stress
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