Acyloxyacyl hydrolase promotes pulmonary defense by preventing alveolar macrophage tolerance

• Xiaofang Cheng ,

  Contributed equally to this work with: Xiaofang Cheng, Wei Jiang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Wei Jiang ,

  Contributed equally to this work with: Xiaofang Cheng, Wei Jiang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Rheumatology and Immunology, the Affiliated Hospital of Guizhou Medical University, Guiyang, China

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• Yeying Chen,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Benkun Zou,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

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• Zhiyan Wang,

  Roles Formal analysis, Investigation

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Lu Gan,

  Roles Formal analysis, Investigation

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Zeling Xiao,

  Roles Investigation

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Changshun Li,

  Roles Investigation

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Cheng-Yun Yu,

  Roles Investigation

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Yimeng Lu,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Zeyao Han,

  Roles Investigation

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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• Jiashun Zeng,

  Roles Methodology, Resources

  Affiliation Department of Rheumatology and Immunology, the Affiliated Hospital of Guizhou Medical University, Guiyang, China

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• Jie Gu,

  Roles Methodology, Resources

  Affiliation Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

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• Tianqing Chu,

  Roles Methodology, Resources

  Affiliation Department of Pulmonary Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China

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• Mingsheng Fu,

  Roles Methodology, Resources

  Affiliation Department of Gastroenterology, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China

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• Yiwei Chu,

  Roles Methodology, Software

  Affiliations Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China, Innovative Center for New Drug Development of Immune Inflammatory Diseases, Ministry of Education, Shanghai, China

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• Wenhong Zhang ,

  Roles Conceptualization, Funding acquisition, Methodology, Resources

  * E-mail: zhangwenhong@fudan.edu.cn (WZ); tangjianguo@5thhospital.com (JT); mingfanglu@fudan.edu.cn (ML)

  Affiliation Shanghai Huashen Institute of Microbes and Infections, Shanghai, China

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• Jianguo Tang ,

  Roles Conceptualization, Funding acquisition, Methodology, Resources

  * E-mail: zhangwenhong@fudan.edu.cn (WZ); tangjianguo@5thhospital.com (JT); mingfanglu@fudan.edu.cn (ML)

  Affiliation Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China

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•  [ ... ],
• Mingfang Lu

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: zhangwenhong@fudan.edu.cn (WZ); tangjianguo@5thhospital.com (JT); mingfanglu@fudan.edu.cn (ML)

  Affiliations Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Disease and Biosecurity, Fudan University, Shanghai, China, Innovative Center for New Drug Development of Immune Inflammatory Diseases, Ministry of Education, Shanghai, China

  https://orcid.org/0000-0002-8612-3444

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