Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals

• Jithesh Kottur ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jithesh.kottur@mssm.edu (JK); aneel.aggarwal@mssm.edu (AA)

  Current address: Department of Antiviral Research, Institute of Advanced Virology, Thiruvananthapuram, Kerala, India

  Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Kris M. White,

  Roles Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• M. Luis Rodriguez,

  Roles Formal analysis, Methodology, Validation, Visualization

  Affiliations Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Olga Rechkoblit,

  Roles Formal analysis

  Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Richard Quintana-Feliciano,

  Roles Formal analysis

  Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Ahana Nayar,

  Roles Formal analysis

  Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Adolfo García-Sastre,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, The Tisch Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

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• Aneel K. Aggarwal

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jithesh.kottur@mssm.edu (JK); aneel.aggarwal@mssm.edu (AA)

  Affiliation Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

  https://orcid.org/0000-0003-4389-0173

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