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Open Access

Peer-reviewed

Research Article

Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype

Ruthiran Kugathasan,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, Imperial College London, London, United Kingdom

https://orcid.org/0000-0002-4591-6026

⨯
Ksenia Sukhova,

Roles Investigation, Methodology

Affiliation Department of Infectious Diseases, Imperial College London, London, United Kingdom
⨯
Maya Moshe,

Roles Investigation, Methodology

Affiliation Department of Infectious Diseases, Imperial College London, London, United Kingdom
⨯
Paul Kellam,

Roles Conceptualization, Resources, Writing – original draft, Writing – review & editing

Affiliations Department of Infectious Diseases, Imperial College London, London, United Kingdom, RQ Biotechnology Ltd, London, United Kingdom
⨯
Wendy Barclay

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: w.barclay@imperial.ac.uk

Affiliation Department of Infectious Diseases, Imperial College London, London, United Kingdom

https://orcid.org/0000-0002-3948-0895

⨯

Deep mutagenesis scanning using whole trimeric SARS-CoV-2 spike highlights the importance of NTD-RBD interactions in determining spike phenotype

Ruthiran Kugathasan,
Ksenia Sukhova,
Maya Moshe,
Paul Kellam,
Wendy Barclay

x

Published: August 3, 2023
https://doi.org/10.1371/journal.ppat.1011545

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Vaccines
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Point mutation
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SARS CoV 2
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Substitution mutation
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