Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

• Merve S. Zeden ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: merve.zeden@universityofgalway.ie (MSZ); jamesp.ogara@universityofgalway.ie (JPO'G)

  Affiliation Microbiology, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland

  https://orcid.org/0000-0003-3636-700X

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• Laura A. Gallagher,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Microbiology, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland

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• Emilio Bueno,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Molecular Biology, Umeå University, MIMS—Laboratory for Molecular Infection Medicine Sweden, Umeå, Sweden

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• Aaron C. Nolan,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Microbiology, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland

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• Jongsam Ahn,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Dhananjay Shinde,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Fareha Razvi,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Margaret Sladek,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Órla Burke,

  Roles Methodology, Writing – review & editing

  Affiliation Microbiology, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland

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• Eoghan O’Neill,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Clinical Microbiology, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Paul D. Fey,

  Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• Felipe Cava,

  Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Molecular Biology, Umeå University, MIMS—Laboratory for Molecular Infection Medicine Sweden, Umeå, Sweden

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• Vinai C. Thomas,

  Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

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• James P. O’Gara

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: merve.zeden@universityofgalway.ie (MSZ); jamesp.ogara@universityofgalway.ie (JPO'G)

  Affiliation Microbiology, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland

  https://orcid.org/0000-0003-3866-7161

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