Designed nanoparticles elicit cross-reactive antibody responses to conserved influenza virus hemagglutinin stem epitopes

• Dustin M. McCraw ,

  Contributed equally to this work with: Dustin M. McCraw, Mallory L. Myers

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: SwanBio Therapeutics, Bala Cynwyd, Pennsylvania, United States of America

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Mallory L. Myers ,

  Contributed equally to this work with: Dustin M. McCraw, Mallory L. Myers

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Neetu M. Gulati,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – original draft

  Current address: Office of International Health and Biodefense, Department of State, Washington D.C., United States of America

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Madhu Prabhakaran,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Joshua Brand,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Current address: McArdle Laboratory of Cancer Research, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Sarah Andrews,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• John R. Gallagher,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Samantha Maldonado-Puga,

  Roles Formal analysis, Methodology, Writing – original draft

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Alexander J. Kim,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Current address: Georgetown University School of Medicine, Washington D.C., United States of America

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Udana Torian,

  Roles Methodology, Writing – original draft

  Current address: Laboratory of Human Carcinogenesis, National Cancer Institute, Bethesda, Maryland, United States of America

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Hubza Syeda,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Seyhan Boyoglu-Barnum,

  Roles Data curation, Formal analysis, Methodology, Supervision

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Masaru Kanekiyo,

  Roles Data curation, Formal analysis, Methodology, Supervision, Writing – original draft

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Adrian B. McDermott,

  Roles Data curation, Formal analysis, Methodology, Supervision, Writing – original draft

  Current address: Sanofi Vaccines, Rockville, Maryland, United States of America

  Affiliation Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Audray K. Harris

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: harrisau@mail.nih.gov

  Affiliation Structural Informatics Unit, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0002-8875-1874

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