Aminopeptidase MNP-1 triggers intestine protease production by activating daf-16 nuclear location to degrade pore-forming toxins in Caenorhabditis elegans

Feng Chen; Cuiyun Pang; Ziqiang Zheng; Wei Zhou; Zhiqing Guo; Danyang Xiao; Hongwen Du; Alejandra Bravo; Mario Soberón; Ming Sun; Donghai Peng

doi:10.1371/journal.ppat.1011507

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Open Access

Peer-reviewed

Research Article

Aminopeptidase MNP-1 triggers intestine protease production by activating daf-16 nuclear location to degrade pore-forming toxins in Caenorhabditis elegans

Feng Chen,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Cuiyun Pang,

Roles Data curation, Investigation, Writing – original draft

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Ziqiang Zheng,

Roles Formal analysis, Visualization

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Wei Zhou,

Roles Data curation, Investigation

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Zhiqing Guo,

Roles Investigation

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Danyang Xiao,

Roles Data curation, Investigation

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Hongwen Du,

Roles Investigation

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Alejandra Bravo,

Roles Writing – review & editing

Affiliation Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico
⨯
Mario Soberón,

Roles Writing – review & editing

Affiliation Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico
⨯
Ming Sun,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China
⨯
Donghai Peng

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: donghaipeng@mail.hzau.edu.cn

Affiliation State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, Hubei, People’s Republic of China

https://orcid.org/0000-0002-4918-2357

⨯

Aminopeptidase MNP-1 triggers intestine protease production by activating daf-16 nuclear location to degrade pore-forming toxins in Caenorhabditis elegans

Feng Chen,
Cuiyun Pang,
Ziqiang Zheng,
Wei Zhou,
Zhiqing Guo,
Danyang Xiao,
Hongwen Du,
Alejandra Bravo,
Mario Soberón,
Ming Sun

Published: July 13, 2023
https://doi.org/10.1371/journal.ppat.1011507

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Toxins
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Caenorhabditis elegans
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Proteases
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Gene expression
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Gastrointestinal tract
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RNA interference
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Escherichia coli
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Gene regulation
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