Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress

Huiyi Li; Shun Liu; Qing Feng; Rilin Deng; Jingjing Wang; Xintao Wang; Renyun Tian; Yan Xu; Shengwen Chen; Qian Liu; Luoling Wang; Xinran Li; Mengyu Wan; Yousong Peng; Songqing Tang; Binbin Xue; Haizhen Zhu

doi:10.1371/journal.ppat.1011443

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Open Access

Peer-reviewed

Research Article

Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress

Huiyi Li,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China

https://orcid.org/0000-0001-9574-7251

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Shun Liu,

Roles Investigation, Resources

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
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Qing Feng,

Roles Investigation, Resources

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
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Rilin Deng,

Roles Formal analysis, Methodology

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Jingjing Wang,

Roles Formal analysis, Investigation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Xintao Wang,

Roles Resources

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Renyun Tian,

Roles Validation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
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Yan Xu,

Roles Validation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Shengwen Chen,

Roles Validation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Qian Liu,

Roles Validation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Luoling Wang,

Roles Validation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Xinran Li,

Roles Investigation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Mengyu Wan,

Roles Investigation

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Yousong Peng,

Roles Methodology

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
⨯
Songqing Tang,

Roles Methodology

Affiliation Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China
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Binbin Xue ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hy0206219@hainmc.edu.cn (BX); hy0206218@hainmc.edu.cn (HZ)

Affiliation Key Laboratory of Tropical Translational Medicine of Ministry of Education, Department of Pathogen Biology and Immunology, Institute of Pathogen Biology and Immunology, School of Basic Medicine and Life Science, The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The First Affiliated Hospital and The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Hainan, China
⨯
[ ... ],
Haizhen Zhu

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: hy0206219@hainmc.edu.cn (BX); hy0206218@hainmc.edu.cn (HZ)

Affiliations Institute of Pathogen Biology and Immunology of College of Biology, Hunan Provincial Key Laboratory of Medical Virology, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha, Hunan, China, Key Laboratory of Tropical Translational Medicine of Ministry of Education, Department of Pathogen Biology and Immunology, Institute of Pathogen Biology and Immunology, School of Basic Medicine and Life Science, The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The First Affiliated Hospital and The Second Affiliated Hospital of Hainan Medical University, Hainan Medical University, Hainan, China

https://orcid.org/0000-0001-5926-6186

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Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress

Huiyi Li,
Shun Liu,
Qing Feng,
Rilin Deng,
Jingjing Wang,
Xintao Wang,
Renyun Tian,
Yan Xu,
Shengwen Chen,
Qian Liu

Published: June 16, 2023
https://doi.org/10.1371/journal.ppat.1011443

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