Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

• Wladimir Malaga ,

  Contributed equally to this work with: Wladimir Malaga, Delphine Payros, Eva Meunier

  Roles Investigation

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Delphine Payros ,

  Contributed equally to this work with: Wladimir Malaga, Delphine Payros, Eva Meunier

  Roles Investigation, Methodology

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Eva Meunier ,

  Contributed equally to this work with: Wladimir Malaga, Delphine Payros, Eva Meunier

  Roles Investigation

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Wafa Frigui,

  Roles Investigation

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR6047, Unit for Integrated Mycobacterial Pathogenomics, Paris, France

  ⨯
• Fadel Sayes,

  Roles Investigation

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR6047, Unit for Integrated Mycobacterial Pathogenomics, Paris, France

  ⨯
• Alexandre Pawlik,

  Roles Investigation

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR6047, Unit for Integrated Mycobacterial Pathogenomics, Paris, France

  ⨯
• Mickael Orgeur,

  Roles Data curation, Investigation, Writing – review & editing

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR6047, Unit for Integrated Mycobacterial Pathogenomics, Paris, France

  ⨯
• Céline Berrone,

  Roles Investigation

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Flavie Moreau,

  Roles Investigation

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Serge Mazères,

  Roles Methodology, Software

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Jesus Gonzalo-Asensio,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliations Grupo de Genética de Micobacterias, Facultad de Medicina, Departamento de Microbiologia, Pediatria, Radiologica y Salud Pùblica, Universidad de Zaragoza, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Institudo de Salud Carlos III, Madrid, Spain

  ⨯
• David Rengel,

  Roles Data curation, Formal analysis

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Carlos Martin,

  Roles Conceptualization, Writing – review & editing

  Affiliations Grupo de Genética de Micobacterias, Facultad de Medicina, Departamento de Microbiologia, Pediatria, Radiologica y Salud Pùblica, Universidad de Zaragoza, Zaragoza, Spain, CIBER Enfermedades Respiratorias, Institudo de Salud Carlos III, Madrid, Spain, Servicio de Microbiologia, Hospital Universitario Miguel Servet, ISS Aragon, Zaragoza, Spain

  ⨯
• Catherine Astarie-Dequeker,

  Roles Data curation, Investigation, Methodology, Writing – review & editing

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  ⨯
• Lionel Mourey ,

  Roles Conceptualization, Data curation, Investigation, Writing – original draft, Writing – review & editing

  * E-mail: Lionel.Mourey@ipbs.fr (LM); roland.brosch@pasteur.fr (RB); Christophe.Guilhot@ipbs.fr (CG)

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  https://orcid.org/0000-0002-8259-1259

  ⨯
• Roland Brosch ,

  Roles Conceptualization, Data curation, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Lionel.Mourey@ipbs.fr (LM); roland.brosch@pasteur.fr (RB); Christophe.Guilhot@ipbs.fr (CG)

  Affiliation Institut Pasteur, Université Paris Cité, CNRS UMR6047, Unit for Integrated Mycobacterial Pathogenomics, Paris, France

  https://orcid.org/0000-0003-2587-3863

  ⨯
•  [ ... ],
• Christophe Guilhot

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: Lionel.Mourey@ipbs.fr (LM); roland.brosch@pasteur.fr (RB); Christophe.Guilhot@ipbs.fr (CG)

  Affiliation Institut de Pharmacologie et de Biologie Structurale (IPBS), Université de Toulouse, CNRS, Université Toulouse III – Paul Sabatier (UPS), Toulouse, France

  https://orcid.org/0000-0002-8052-4685

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