Upregulation of LAG3 modulates the immune imbalance of CD4+ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model

Dewei Li; Abidan Ainiwaer; Xuran Zheng; Maolin Wang; Yang Shi; Zibigu Rousu; Xinling Hou; Xuejiao Kang; Muesier Maimaiti; Hui Wang; Jing Li; Chuanshan Zhang

doi:10.1371/journal.ppat.1011396

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Open Access

Peer-reviewed

Research Article

Upregulation of LAG3 modulates the immune imbalance of CD4⁺ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model

Dewei Li ,

Contributed equally to this work with: Dewei Li, Abidan Ainiwaer, Xuran Zheng

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Abidan Ainiwaer ,

Contributed equally to this work with: Dewei Li, Abidan Ainiwaer, Xuran Zheng

Roles Data curation

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Xuran Zheng ,

Contributed equally to this work with: Dewei Li, Abidan Ainiwaer, Xuran Zheng

Roles Data curation

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Maolin Wang,

Roles Methodology, Resources

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Yang Shi,

Roles Data curation

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Zibigu Rousu,

Roles Methodology, Resources

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Xinling Hou,

Roles Data curation

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Xuejiao Kang,

Roles Methodology, Resources

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Muesier Maimaiti,

Roles Methodology

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Hui Wang ,

Roles Formal analysis, Investigation, Supervision, Writing – review & editing

* E-mail: wangh0923@126.com (HW); lijing0527@163.com (JL); dashan0518@126.com (CZ)

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China, Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and WHO Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, Xinjiang, China
⨯
Jing Li ,

Roles Conceptualization, Funding acquisition, Project administration, Writing – original draft

* E-mail: wangh0923@126.com (HW); lijing0527@163.com (JL); dashan0518@126.com (CZ)

Affiliation Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China
⨯
Chuanshan Zhang

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: wangh0923@126.com (HW); lijing0527@163.com (JL); dashan0518@126.com (CZ)

Affiliations State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China, Basic Medical College, Xinjiang Medical University, Urumqi, Xinjiang, China, Xinjiang Key Laboratory of Echinococcosis, Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University, and WHO Collaborating Centre on Prevention and Case Management of Echinococcosis, Urumqi, Xinjiang, China

https://orcid.org/0000-0002-3241-2224

⨯

Upregulation of LAG3 modulates the immune imbalance of CD4⁺ T-cell subsets and exacerbates disease progression in patients with alveolar echinococcosis and a mouse model

Dewei Li,
Abidan Ainiwaer,
Xuran Zheng,
Maolin Wang,
Yang Shi,
Zibigu Rousu,
Xinling Hou,
Xuejiao Kang,
Muesier Maimaiti,
Hui Wang

Published: May 12, 2023
https://doi.org/10.1371/journal.ppat.1011396

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