Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

Xianghui Liang; Xiaoyuan Chen; Junqiong Zhai; Xiaobing Li; Xu Zhang; Zhipeng Zhang; Ping Zhang; Xiao Wang; Xinyuan Cui; Hai Wang; Niu Zhou; Zu-Jin Chen; Renwei Su; Fuqing Zhou; Edward C. Holmes; David M. Irwin; Rui-Ai Chen; Qian He; Ya-Jiang Wu; Chen Wang; Xue-Qing Du; Shi-Ming Peng; Wei-Jun Xie; Fen Shan; Wan-Ping Li; Jun-Wei Dai; Xuejuan Shen; Yaoyu Feng; Lihua Xiao; Wu Chen; Yongyi Shen

doi:10.1371/journal.ppat.1011384

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Open Access

Peer-reviewed

Research Article

Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

Xianghui Liang ,

Contributed equally to this work with: Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang

Roles Investigation, Validation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Xiaoyuan Chen ,

Contributed equally to this work with: Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Junqiong Zhai ,

Contributed equally to this work with: Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang

Roles Investigation, Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Xiaobing Li ,

Contributed equally to this work with: Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, College of Life Sciences, Longyan University, Longyan, China
⨯
Xu Zhang ,

Contributed equally to this work with: Xianghui Liang, Xiaoyuan Chen, Junqiong Zhai, Xiaobing Li, Xu Zhang

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Zhipeng Zhang,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Ping Zhang,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Xiao Wang,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Xinyuan Cui,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Hai Wang,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Niu Zhou,

Roles Investigation, Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Zu-Jin Chen,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Renwei Su,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Fuqing Zhou,

Roles Investigation

Affiliation Department of Radiology, the First Affiliated Hospital, Nanchang University, Nanchang, China
⨯
Edward C. Holmes,

Roles Investigation, Writing – review & editing

Affiliation Sydney Institute for Infectious Diseases, School of Medical Sciences, University of Sydney, Sydney, New South Wales, Australia
⨯
David M. Irwin,

Roles Writing – review & editing

Affiliations Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, Banting and Best Diabetes Centre, University of Toronto, Toronto, Canada
⨯
Rui-Ai Chen,

Roles Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Zhaoqing Branch Center of Guangdong Laboratory for Lingnan Modern Agricultural Science and Technology, Zhaoqing, China
⨯
Qian He,

Roles Investigation

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Ya-Jiang Wu,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Chen Wang,

Roles Software

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Xue-Qing Du,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Shi-Ming Peng,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Wei-Jun Xie,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Fen Shan,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Wan-Ping Li,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Jun-Wei Dai,

Roles Resources

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
Xuejuan Shen,

Roles Investigation, Project administration

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Yaoyu Feng,

Roles Writing – review & editing

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Lihua Xiao,

Roles Writing – review & editing

Affiliation State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Wu Chen ,

Roles Investigation, Resources, Supervision, Writing – review & editing

* E-mail: guangzhouchenwu@sina.com (WC); shenyy@scau.edu.cn (YS)

Affiliation Guangzhou Zoo & Guangzhou Wildlife Research Center, Guangzhou, China
⨯
[ ... ],
Yongyi Shen

Roles Data curation, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft

* E-mail: guangzhouchenwu@sina.com (WC); shenyy@scau.edu.cn (YS)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, Guangdong Laboratory for Lingnan Modern Agriculture, Center for Emerging and Zoonotic Diseases, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, Guangzhou, China

https://orcid.org/0000-0001-7660-5522

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Pathogenicity, tissue tropism and potential vertical transmission of SARSr-CoV-2 in Malayan pangolins

Xianghui Liang,
Xiaoyuan Chen,
Junqiong Zhai,
Xiaobing Li,
Xu Zhang,
Zhipeng Zhang,
Ping Zhang,
Xiao Wang,
Xinyuan Cui,
Hai Wang

Published: May 17, 2023
https://doi.org/10.1371/journal.ppat.1011384

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