Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo

Nirmal Kumar; Irshad Maajid Taily; Charandeep Singh; Sahil Kumar; Raju S. Rajmani; Debajyoti Chakraborty; Anshul Sharma; Priyanka Singh; Krishan Gopal Thakur; Raghavan Varadarajan; Rajesh P. Ringe; Prabal Banerjee; Indranil Banerjee

doi:10.1371/journal.ppat.1011358

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Open Access

Peer-reviewed

Research Article

Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo

Nirmal Kumar,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Cellular Virology Lab, Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali (IISER Mohali), Mohali, India
⨯
Irshad Maajid Taily,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Punjab, India
⨯
Charandeep Singh,

Roles Investigation

Affiliation Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR-IMTECH), Chandigarh, India
⨯
Sahil Kumar,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR-IMTECH), Chandigarh, India
⨯
Raju S. Rajmani,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Molecular Biophysics Unit, Indian Institute of Science, Bangalore (IISc), Bengaluru, India
⨯
Debajyoti Chakraborty,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation

Affiliation Molecular Biophysics Unit, Indian Institute of Science, Bangalore (IISc), Bengaluru, India
⨯
Anshul Sharma,

Roles Investigation

Affiliation Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR-IMTECH), Chandigarh, India
⨯
Priyanka Singh,

Roles Investigation

Affiliation Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Punjab, India
⨯
Krishan Gopal Thakur,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision

Affiliation Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR-IMTECH), Chandigarh, India
⨯
Raghavan Varadarajan,

Roles Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Molecular Biophysics Unit, Indian Institute of Science, Bangalore (IISc), Bengaluru, India
⨯
Rajesh P. Ringe ,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: rajeshringe@imtech.res.in (RPR); prabal@iitrpr.ac.in (PB); indranil@iisermohali.ac.in (IB)

Affiliation Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR-IMTECH), Chandigarh, India
⨯
Prabal Banerjee ,

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: rajeshringe@imtech.res.in (RPR); prabal@iitrpr.ac.in (PB); indranil@iisermohali.ac.in (IB)

Affiliation Department of Chemistry, Indian Institute of Technology Ropar (IIT Ropar), Rupnagar, Punjab, India
⨯
Indranil Banerjee

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: rajeshringe@imtech.res.in (RPR); prabal@iitrpr.ac.in (PB); indranil@iisermohali.ac.in (IB)

Affiliation Cellular Virology Lab, Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali (IISER Mohali), Mohali, India

https://orcid.org/0000-0002-0808-2392

⨯

Identification of diphenylurea derivatives as novel endocytosis inhibitors that demonstrate broad-spectrum activity against SARS-CoV-2 and influenza A virus both in vitro and in vivo

Nirmal Kumar,
Irshad Maajid Taily,
Charandeep Singh,
Sahil Kumar,
Raju S. Rajmani,
Debajyoti Chakraborty,
Anshul Sharma,
Priyanka Singh,
Krishan Gopal Thakur,
Raghavan Varadarajan

Published: May 1, 2023
https://doi.org/10.1371/journal.ppat.1011358

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