The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress

• Ka Pui Sharon Yau ,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Infection Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia, Centre to Impact AMR, Monash University, Clayton, Victoria, Australia

  ⨯
• Harshini Weerasinghe ,

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Infection Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia, Centre to Impact AMR, Monash University, Clayton, Victoria, Australia

  ⨯
• Francios A. B. Olivier,

  Roles Conceptualization, Formal analysis, Investigation

  Affiliations Infection Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia, Centre to Impact AMR, Monash University, Clayton, Victoria, Australia

  ⨯
• Tricia L. Lo,

  Roles Investigation

  Affiliations Infection Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia, Centre to Impact AMR, Monash University, Clayton, Victoria, Australia

  ⨯
• David R. Powell,

  Roles Formal analysis, Investigation

  Affiliation Bioinformatics Platform, Monash University, Clayton, Victoria, Australia

  ⨯
• Barbara Koch,

  Roles Conceptualization, Supervision

  Current address: MSD, 26 Talavera Road, NSW, Australia

  Affiliation Infection Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

  ⨯
• Traude H. Beilharz,

  Roles Conceptualization, Formal analysis, Funding acquisition, Supervision

  Affiliation Development and Stem Cells Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia

  ⨯
• Ana Traven

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: ana.traven@monash.edu

  Affiliations Infection Program, Department of Biochemistry & Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia, Centre to Impact AMR, Monash University, Clayton, Victoria, Australia

  https://orcid.org/0000-0001-6252-3104

  ⨯