Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C/EBPβ pathway during Toxoplasma gondii infection

Houbao Qi; Yuantao Li; Xianbing Liu; Yuzhu Jiang; Zhidan Li; Xiaoyan Xu; Haixia Zhang; Xuemei Hu

doi:10.1371/journal.ppat.1011329

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Open Access

Peer-reviewed

Research Article

Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C/EBPβ pathway during Toxoplasma gondii infection

Houbao Qi ,

Contributed equally to this work with: Houbao Qi, Yuantao Li, Xianbing Liu

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Yuantao Li ,

Contributed equally to this work with: Houbao Qi, Yuantao Li, Xianbing Liu

Roles Data curation, Formal analysis, Investigation, Validation, Writing – original draft

Affiliation Department of Gynecology and Obstetrics, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Xianbing Liu ,

Contributed equally to this work with: Houbao Qi, Yuantao Li, Xianbing Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Yuzhu Jiang,

Roles Formal analysis, Methodology, Resources

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Zhidan Li,

Roles Investigation, Methodology, Resources

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Xiaoyan Xu,

Roles Investigation

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Haixia Zhang,

Roles Formal analysis

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China
⨯
Xuemei Hu

Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

* E-mail: xue-mei-hu@163.com

Affiliation Department of Immunology, Binzhou Medical University, Yantai, Shandong, P. R. China

https://orcid.org/0000-0003-3584-5639

⨯

Tim-3 regulates the immunosuppressive function of decidual MDSCs via the Fyn-STAT3-C/EBPβ pathway during Toxoplasma gondii infection

Houbao Qi,
Yuantao Li,
Xianbing Liu,
Yuzhu Jiang,
Zhidan Li,
Xiaoyan Xu,
Haixia Zhang,
Xuemei Hu

Published: April 14, 2023
https://doi.org/10.1371/journal.ppat.1011329

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Toxoplasma gondii
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Flow cytometry
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Immunosuppressives
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STAT signaling
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