Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

Xiaodi Yu; Jarek Juraszek; Lucy Rutten; Mark J. G. Bakkers; Sven Blokland; Jelle M. Melchers; Niels J. F. van den Broek; Annemiek Y. W. Verwilligen; Pravien Abeywickrema; Johan Vingerhoets; Jean-Marc Neefs; Shah A. Mohamed Bakhash; Pavitra Roychoudhury; Alex Greninger; Sujata Sharma; Johannes P. M. Langedijk

doi:10.1371/journal.ppat.1011308

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Open Access

Peer-reviewed

Research Article

Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

Xiaodi Yu ,

Contributed equally to this work with: Xiaodi Yu, Jarek Juraszek

Roles Conceptualization, Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America

https://orcid.org/0000-0001-7520-0646

⨯
Jarek Juraszek ,

Contributed equally to this work with: Xiaodi Yu, Jarek Juraszek

Roles Conceptualization, Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Lucy Rutten,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Mark J. G. Bakkers,

Roles Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Sven Blokland,

Roles Data curation, Formal analysis

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Jelle M. Melchers,

Roles Data curation, Formal analysis

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Niels J. F. van den Broek,

Roles Data curation, Formal analysis

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Annemiek Y. W. Verwilligen,

Roles Data curation, Formal analysis

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands
⨯
Pravien Abeywickrema,

Roles Data curation, Formal analysis

Affiliation Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America
⨯
Johan Vingerhoets,

Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing

Affiliation Janssen Pharmaceutica N.V., Clinical Microbiology and Immunology, Beerse, Belgium
⨯
Jean-Marc Neefs,

Roles Data curation, Formal analysis

Affiliation Janssen Pharmaceutica N.V., Discovery Sciences, Beerse, Belgium
⨯
Shah A. Mohamed Bakhash,

Roles Data curation, Formal analysis

Affiliation Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America
⨯
Pavitra Roychoudhury,

Roles Data curation, Formal analysis

Affiliation Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America
⨯
Alex Greninger,

Roles Data curation, Formal analysis

Affiliation Department of Laboratory Medicine and Pathology, Virology Division, University of Washington, Seattle, Washington, United States of America
⨯
Sujata Sharma,

Roles Supervision, Writing – original draft, Writing – review & editing

Affiliation Structural & Protein Sciences, Janssen Research and Development, Spring House, Pennsylvania, United States of America
⨯
[ ... ],
Johannes P. M. Langedijk

Roles Conceptualization, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hlangedi@its.jnj.com

Affiliation Janssen Vaccines & Prevention BV, Leiden, the Netherlands

https://orcid.org/0000-0001-8768-0982

⨯
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Convergence of immune escape strategies highlights plasticity of SARS-CoV-2 spike

Xiaodi Yu,
Jarek Juraszek,
Lucy Rutten,
Mark J. G. Bakkers,
Sven Blokland,
Jelle M. Melchers,
Niels J. F. van den Broek,
Annemiek Y. W. Verwilligen,
Pravien Abeywickrema,
Johan Vingerhoets

Published: May 1, 2023
https://doi.org/10.1371/journal.ppat.1011308

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