N6-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication

Yinxing Zhu; Ruifang Wang; Jiahui Zou; Shan Tian; Luyao Yu; Yuanbao Zhou; Ying Ran; Meilin Jin; Huanchun Chen; Hongbo Zhou

doi:10.1371/journal.ppat.1011305

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Open Access

Peer-reviewed

Research Article

N⁶-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication

Yinxing Zhu ,

Contributed equally to this work with: Yinxing Zhu, Ruifang Wang, Jiahui Zou

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Ruifang Wang ,

Contributed equally to this work with: Yinxing Zhu, Ruifang Wang, Jiahui Zou

Roles Conceptualization, Data curation, Methodology, Writing – review & editing

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Jiahui Zou ,

Contributed equally to this work with: Yinxing Zhu, Ruifang Wang, Jiahui Zou

Roles Data curation, Investigation, Methodology, Validation

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Shan Tian,

Roles Data curation, Investigation, Validation

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Luyao Yu,

Roles Data curation, Investigation, Validation

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Yuanbao Zhou,

Roles Data curation

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Ying Ran,

Roles Data curation, Investigation, Validation

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Meilin Jin,

Roles Methodology

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China
⨯
Huanchun Chen,

Roles Methodology

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Hubei Hongshan Laboratory, Wuhan, China
⨯
Hongbo Zhou

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: hbzhou@mail.hzau.edu.cn

Affiliations State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China, Key Laboratory of Preventive Veterinary Medicine in Hubei Province, Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China, Hubei Hongshan Laboratory, Wuhan, China

https://orcid.org/0000-0002-3954-3972

⨯

N⁶-methyladenosine reader protein YTHDC1 regulates influenza A virus NS segment splicing and replication

Yinxing Zhu,
Ruifang Wang,
Jiahui Zou,
Shan Tian,
Luyao Yu,
Yuanbao Zhou,
Ying Ran,
Meilin Jin,
Huanchun Chen,
Hongbo Zhou

Published: April 13, 2023
https://doi.org/10.1371/journal.ppat.1011305

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Influenza A virus
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RNA splicing
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Immunoprecipitation
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