Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling

Chrissy M. Leopold Wager; Jordan R. Bonifacio; Jan Simper; Adrian A. Naoun; Eusondia Arnett; Larry S. Schlesinger

doi:10.1371/journal.ppat.1011297

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Peer-reviewed

Research Article

Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling

Chrissy M. Leopold Wager ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: cwager@txbiomed.org (CMLW); lschlesinger@txbiomed.org (LSS)

Affiliation Host Pathogen Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Jordan R. Bonifacio,

Roles Formal analysis, Investigation

Affiliation Host Pathogen Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Jan Simper,

Roles Formal analysis, Investigation

Affiliations Host Pathogen Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America, Medical Scientist Training Program, Department of Microbiology, Immunology and Molecular Genetics, UT Health Science Center San Antonio, San Antonio, Texas, United States of America
⨯
Adrian A. Naoun,

Roles Formal analysis, Investigation

Current Address: Department of Medicine, San Juan Bautista University, Caguas, Puerto Rico, United States of America

Affiliation Department of Biology, The University of Texas at San Antonio, San Antonio, Texas, United States of America
⨯
Eusondia Arnett,

Roles Writing – review & editing

Affiliation Host Pathogen Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America
⨯
Larry S. Schlesinger

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: cwager@txbiomed.org (CMLW); lschlesinger@txbiomed.org (LSS)

Affiliation Host Pathogen Interaction Program, Texas Biomedical Research Institute, San Antonio, Texas, United States of America

https://orcid.org/0000-0002-7177-8421

⨯

Activation of transcription factor CREB in human macrophages by Mycobacterium tuberculosis promotes bacterial survival, reduces NF-kB nuclear transit and limits phagolysosome fusion by reduced necroptotic signaling

Chrissy M. Leopold Wager,
Jordan R. Bonifacio,
Jan Simper,
Adrian A. Naoun,
Eusondia Arnett,
Larry S. Schlesinger

Published: March 31, 2023
https://doi.org/10.1371/journal.ppat.1011297

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Macrophages
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Phosphorylation
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CREB signaling
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Signal inhibition
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Gene expression
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Transcription factors
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Bacterial growth
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Small interfering RNA
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