Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir

• Shiho Torii ,

  Contributed equally to this work with: Shiho Torii, Kwang Su Kim, Jun Koseki, Rigel Suzuki

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Insect-Virus Interactions Unit, Department of Virology, Institute Pasteur, Paris, France

  Affiliation Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Suita, Japan

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• Kwang Su Kim ,

  Contributed equally to this work with: Shiho Torii, Kwang Su Kim, Jun Koseki, Rigel Suzuki

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Scientific computing, Pukyong National University, Busan, South Korea

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Jun Koseki ,

  Contributed equally to this work with: Shiho Torii, Kwang Su Kim, Jun Koseki, Rigel Suzuki

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Systems Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Rigel Suzuki ,

  Contributed equally to this work with: Shiho Torii, Kwang Su Kim, Jun Koseki, Rigel Suzuki

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan

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• Shoya Iwanami,

  Roles Investigation, Methodology, Software

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Yasuhisa Fujita,

  Roles Investigation, Methodology

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Yong Dam Jeong,

  Roles Investigation, Methodology

  Affiliation interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan

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• Jumpei Ito,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Hiroyuki Asakura,

  Roles Investigation, Methodology

  Affiliation Tokyo Metropolitan Institute of Public Health, Tokyo, Japan

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• Mami Nagashima,

  Roles Investigation, Methodology

  Affiliation Tokyo Metropolitan Institute of Public Health, Tokyo, Japan

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• Kenji Sadamasu,

  Roles Investigation, Methodology

  Affiliation Tokyo Metropolitan Institute of Public Health, Tokyo, Japan

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• Kazuhisa Yoshimura,

  Roles Investigation, Methodology

  Affiliation Tokyo Metropolitan Institute of Public Health, Tokyo, Japan

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• The Genotype to Phenotype Japan (G2P-Japan) Consortium ,

  ¶Membership of The Genotype to Phenotype Japan (G2P-Japan) Consortium is provided in Supporting Information file [S1 Acknowledgement].

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• Kei Sato,

  Roles Supervision

  Affiliations Division of Systems Virology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Japan

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• Yoshiharu Matsuura ,

  Roles Investigation, Methodology, Supervision

  * E-mail: matsuura@biken.osaka-u.ac.jp(YM); shimamura@med.nagoya-u.ac.jp (TS); iwami.iblab@bio.nagoya-u.ac.jp (SI); fukut@pop.med.hokudai.ac.jp (TF)

  Affiliations Laboratory of Virus Control, Research Institute for Microbial Diseases, Osaka University, Suita, Japan, Center for Infectious Disease Education and Research, Osaka University, Suita, Japan

  https://orcid.org/0000-0001-9091-8285

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• Teppei Shimamura ,

  Roles Conceptualization, Funding acquisition, Methodology, Software, Supervision, Validation, Writing – review & editing

  * E-mail: matsuura@biken.osaka-u.ac.jp(YM); shimamura@med.nagoya-u.ac.jp (TS); iwami.iblab@bio.nagoya-u.ac.jp (SI); fukut@pop.med.hokudai.ac.jp (TF)

  Affiliation Division of Systems Biology, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Shingo Iwami ,

  Roles Conceptualization, Funding acquisition, Methodology, Software, Supervision, Validation, Writing – review & editing

  * E-mail: matsuura@biken.osaka-u.ac.jp(YM); shimamura@med.nagoya-u.ac.jp (TS); iwami.iblab@bio.nagoya-u.ac.jp (SI); fukut@pop.med.hokudai.ac.jp (TF)

  Affiliations interdisciplinary Biology Laboratory (iBLab), Division of Biological Science, Graduate School of Science, Nagoya University, Nagoya, Japan, Institute of Mathematics for Industry, Kyushu University, Fukuoka, Japan, Institute for the Advanced Study of Human Biology (ASHBi), Kyoto University, Kyoto, Japan, NEXT-Ganken Program, Japanese Foundation for Cancer Research (JFCR), Tokyo, Japan, Interdisciplinary Theoretical and Mathematical Sciences Program (iTHEMS), RIKEN, Saitama, Japan, Science Groove Inc., Fukuoka, Japan

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•  [ ... ],
• Takasuke Fukuhara

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: matsuura@biken.osaka-u.ac.jp(YM); shimamura@med.nagoya-u.ac.jp (TS); iwami.iblab@bio.nagoya-u.ac.jp (SI); fukut@pop.med.hokudai.ac.jp (TF)

  Affiliations Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan, AMED-CREST, Japan Agency for Medical Research and Development (AMED), Tokyo, Japan

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