Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range

• Dongchun Ni,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Biological Electron Microscopy (LBEM), Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Dep. of Fund. Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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• Priscilla Turelli,

  Roles Conceptualization, Formal analysis, Resources, Supervision, Writing – review & editing

  Affiliation Laboratory of Virology and Genetics (LVG), School of Life Sciences, École polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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• Bertrand Beckert,

  Roles Investigation, Methodology

  Affiliation Dubochet Center for Imaging (DCI), École polytechnique Fédérale de Lausanne (EPFL) and University of Lausanne, Lausanne, Switzerland

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• Sergey Nazarov,

  Roles Investigation, Methodology

  Affiliation Dubochet Center for Imaging (DCI), École polytechnique Fédérale de Lausanne (EPFL) and University of Lausanne, Lausanne, Switzerland

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• Emiko Uchikawa,

  Roles Investigation, Methodology

  Affiliation Dubochet Center for Imaging (DCI), École polytechnique Fédérale de Lausanne (EPFL) and University of Lausanne, Lausanne, Switzerland

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• Alexander Myasnikov,

  Roles Investigation, Methodology

  Affiliation Dubochet Center for Imaging (DCI), École polytechnique Fédérale de Lausanne (EPFL) and University of Lausanne, Lausanne, Switzerland

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• Florence Pojer,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Protein Production and Structure Characterization Core Facility (PTPSP), School of Life Sciences, École polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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• Didier Trono,

  Roles Conceptualization, Resources, Supervision

  Affiliation Laboratory of Virology and Genetics (LVG), School of Life Sciences, École polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

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• Henning Stahlberg ,

  Roles Funding acquisition, Investigation, Resources, Supervision, Writing – review & editing

  * E-mail: henning.stahlberg@epfl.ch (HS); kelvin.lau@epfl.ch (KL)

  Affiliations Laboratory of Biological Electron Microscopy (LBEM), Institute of Physics, School of Basic Science, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, Dep. of Fund. Microbiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland

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• Kelvin Lau

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: henning.stahlberg@epfl.ch (HS); kelvin.lau@epfl.ch (KL)

  Affiliation Protein Production and Structure Characterization Core Facility (PTPSP), School of Life Sciences, École polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

  https://orcid.org/0000-0002-9040-7597

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