BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies

Janmejay Singh; Anbalagan Anantharaj; Aleksha Panwar; Chitra Rani; Monika Bhardwaj; Parveen Kumar; Partha Chattopadhyay; Priti Devi; Ranjeet Maurya; Pallavi Mishra; Anil Kumar Pandey; Rajesh Pandey; Guruprasad R. Medigeshi

doi:10.1371/journal.ppat.1011196

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Open Access

Peer-reviewed

Research Article

BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies

Janmejay Singh ,

Contributed equally to this work with: Janmejay Singh, Anbalagan Anantharaj

Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India
⨯
Anbalagan Anantharaj ,

Contributed equally to this work with: Janmejay Singh, Anbalagan Anantharaj

Roles Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India
⨯
Aleksha Panwar,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India
⨯
Chitra Rani,

Roles Formal analysis, Investigation, Methodology

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India
⨯
Monika Bhardwaj,

Roles Formal analysis, Investigation, Methodology

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India
⨯
Parveen Kumar,

Roles Formal analysis, Investigation, Methodology

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India
⨯
Partha Chattopadhyay,

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliations INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Priti Devi,

Roles Data curation, Formal analysis, Investigation, Methodology, Software

Affiliations INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Ranjeet Maurya,

Roles Formal analysis, Investigation, Methodology, Software, Validation

Affiliations INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
⨯
Pallavi Mishra,

Roles Formal analysis, Investigation, Methodology, Software, Validation

Affiliation INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
⨯
Anil Kumar Pandey,

Roles Conceptualization, Data curation, Formal analysis, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Employees State Insurance Corporation Medical College and Hospital, Faridabad, Haryana, India
⨯
Rajesh Pandey,

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

Affiliation INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of Genomics and Integrative Biology, Delhi, India
⨯
Guruprasad R. Medigeshi

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: gmedigeshi@thsti.res.in

Affiliation Bioassay Laboratory and Clinical and Cellular Virology Laboratory, Translational Health Science and Technology Institute, Faridabad, Haryana, India

https://orcid.org/0000-0001-5333-9743

⨯

BA.1, BA.2 and BA.2.75 variants show comparable replication kinetics, reduced impact on epithelial barrier and elicit cross-neutralizing antibodies

Janmejay Singh,
Anbalagan Anantharaj,
Aleksha Panwar,
Chitra Rani,
Monika Bhardwaj,
Parveen Kumar,
Partha Chattopadhyay,
Priti Devi,
Ranjeet Maurya,
Pallavi Mishra

Published: February 24, 2023
https://doi.org/10.1371/journal.ppat.1011196
See the preprint

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