Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1

Wai-Yin Lui; Aradhana Bharti; Nok-Hei Mickey Wong; Sonia Jangra; Michael G. Botelho; Kit-San Yuen; Dong-Yan Jin

doi:10.1371/journal.ppat.1011186

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Peer-reviewed

Research Article

Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1

Wai-Yin Lui,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Biomedical Sciences, the University of Hong Kong, Pokfulam, Hong Kong
⨯
Aradhana Bharti,

Roles Data curation, Investigation, Writing – review & editing

Affiliation Faculty of Dentistry, the University of Hong Kong, Sai Yin Pun, Hong Kong
⨯
Nok-Hei Mickey Wong,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Current address: Department of Haematological Medicine, Division of Cancer Studies, Leukemia and Stem Cell Biology Team, King’s College London, London, United Kingdom

Affiliation School of Biomedical Sciences, the University of Hong Kong, Pokfulam, Hong Kong
⨯
Sonia Jangra,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

Current address: Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America

Affiliation Faculty of Dentistry, the University of Hong Kong, Sai Yin Pun, Hong Kong
⨯
Michael G. Botelho,

Roles Data curation, Formal analysis, Supervision, Writing – review & editing

Affiliation Faculty of Dentistry, the University of Hong Kong, Sai Yin Pun, Hong Kong
⨯
Kit-San Yuen ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – review & editing

* E-mail: samyuen@hku.hk (K-SY); dyjin@hku.hk (D-YJ)

Affiliations School of Biomedical Sciences, the University of Hong Kong, Pokfulam, Hong Kong, School of Nursing, Tung Wah College, Kowloon, Hong Kong
⨯
Dong-Yan Jin

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: samyuen@hku.hk (K-SY); dyjin@hku.hk (D-YJ)

Affiliation School of Biomedical Sciences, the University of Hong Kong, Pokfulam, Hong Kong

https://orcid.org/0000-0002-2778-3530

⨯

Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1

Wai-Yin Lui,
Aradhana Bharti,
Nok-Hei Mickey Wong,
Sonia Jangra,
Michael G. Botelho,
Kit-San Yuen,
Dong-Yan Jin

Published: February 21, 2023
https://doi.org/10.1371/journal.ppat.1011186

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Ubiquitination
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Transfection
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Plasmid construction
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Co-immunoprecipitation
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Transcription factors
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Epstein-Barr virus
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Nasopharyngeal carcinoma
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Dimerization
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