The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling

• Emmely E. Treffers,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands, Center for Proteomics & Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Ali Tas,

  Roles Investigation

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Florine E. M. Scholte,

  Roles Investigation, Writing – review & editing

  Current address: Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Arnoud H. de Ru,

  Roles Data curation, Investigation

  Affiliation Center for Proteomics & Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Eric J. Snijder,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Peter A. van Veelen ,

  Contributed equally to this work with: Peter A. van Veelen, Martijn J. van Hemert

  Roles Conceptualization, Data curation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Center for Proteomics & Metabolomics, Leiden University Medical Center, Leiden, The Netherlands

  ⨯
• Martijn J. van Hemert

  Contributed equally to this work with: Peter A. van Veelen, Martijn J. van Hemert

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: m.j.van_hemert@lumc.nl

  Affiliation Molecular Virology Laboratory, Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands

  https://orcid.org/0000-0002-2617-9243

  ⨯