Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA release

• Huisheng Liu ,

  Contributed equally to this work with: Huisheng Liu, Zixiang Zhu, Qiao Xue

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Zixiang Zhu ,

  Contributed equally to this work with: Huisheng Liu, Zixiang Zhu, Qiao Xue

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Qiao Xue ,

  Contributed equally to this work with: Huisheng Liu, Zixiang Zhu, Qiao Xue

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Fan Yang,

  Roles Conceptualization, Investigation, Methodology, Resources

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Zongqiang Li,

  Roles Conceptualization, Formal analysis, Resources, Software

  Affiliation State Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China

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• Zhaoning Xue,

  Roles Conceptualization, Formal analysis, Methodology

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Weijun Cao,

  Roles Conceptualization, Data curation, Methodology

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Jijun He,

  Roles Resources, Writing – review & editing

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Jianhong Guo,

  Roles Methodology, Resources

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Xiangtao Liu,

  Roles Funding acquisition, Supervision

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

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• Andrew E. Shaw,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom

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• Donald P. King,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliation The Pirbright Institute, Pirbright, Surrey, United Kingdom

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• Haixue Zheng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: haixuezheng@163.com

  Affiliation State Key Laboratory of Veterinary Etiological Biology; College of Veterinary Medicine, Lanzhou University, WOAH/National reference laboratory for foot-and-mouth disease; Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China

  https://orcid.org/0000-0002-1644-2300

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