Targeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entry

Qiyu Tong; Geng Liu; Xiongbo Sang; Xinyue Zhu; Xiaoli Fu; Chao Dou; Yue Jian; Jiani Zhang; Sailan Zou; Guixiang Zhang; Xiao Du; Dan Liu; Shiqian Qi; Wei Cheng; Yan Tian; Xianghui Fu

doi:10.1371/journal.ppat.1011131

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Open Access

Peer-reviewed

Research Article

Targeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entry

Qiyu Tong ,

Contributed equally to this work with: Qiyu Tong, Geng Liu

Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
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Geng Liu ,

Contributed equally to this work with: Qiyu Tong, Geng Liu

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
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Xiongbo Sang,

Roles Data curation, Methodology

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
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Xinyue Zhu,

Roles Data curation

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
⨯
Xiaoli Fu,

Roles Data curation, Methodology

Affiliation Division of Pulmonary and Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⨯
Chao Dou,

Roles Data curation

Affiliation Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
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Yue Jian,

Roles Formal analysis

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
⨯
Jiani Zhang,

Roles Formal analysis

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
⨯
Sailan Zou,

Roles Methodology

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
⨯
Guixiang Zhang,

Roles Formal analysis

Affiliation Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⨯
Xiao Du,

Roles Formal analysis

Affiliation Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⨯
Dan Liu,

Roles Formal analysis, Funding acquisition

Affiliation Division of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⨯
Shiqian Qi,

Roles Formal analysis

Affiliation Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⨯
Wei Cheng,

Roles Formal analysis, Visualization

Affiliation Division of Pulmonary and Critical Care Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China
⨯
Yan Tian ,

Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: tyfxh@163.com (YT); xfu@scu.edu.cn (XF)

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China
⨯
[ ... ],
Xianghui Fu

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: tyfxh@163.com (YT); xfu@scu.edu.cn (XF)

Affiliation Division of Endocrinology and Metabolism, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, China

https://orcid.org/0000-0001-9808-3892

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Targeting RNA G-quadruplex with repurposed drugs blocks SARS-CoV-2 entry

Qiyu Tong,
Geng Liu,
Xiongbo Sang,
Xinyue Zhu,
Xiaoli Fu,
Chao Dou,
Yue Jian,
Jiani Zhang,
Sailan Zou,
Guixiang Zhang

Published: January 26, 2023
https://doi.org/10.1371/journal.ppat.1011131

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