Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

Manickam Yogavel; Alexandre Bougdour; Siddhartha Mishra; Nipun Malhotra; Jyoti Chhibber-Goel; Valeria Bellini; Karl Harlos; Benoît Laleu; Mohamed-Ali Hakimi; Amit Sharma

doi:10.1371/journal.ppat.1011124

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Peer-reviewed

Research Article

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

Manickam Yogavel ,

Contributed equally to this work with: Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra

Roles Data curation, Formal analysis, Project administration, Validation, Writing – review & editing

Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India
⨯
Alexandre Bougdour ,

Contributed equally to this work with: Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France
⨯
Siddhartha Mishra ,

Contributed equally to this work with: Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliations Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India, ICMR-National Institute of Malaria Research, Dwarka, New Delhi, India
⨯
Nipun Malhotra ,

Contributed equally to this work with: Manickam Yogavel, Alexandre Bougdour, Siddhartha Mishra, Nipun Malhotra

Roles Data curation, Investigation, Methodology, Writing – review & editing

Current address: David Heart and Lung Institute, Wexner Medical Center, The Ohio State University, Columbus, United States of America

Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India
⨯
Jyoti Chhibber-Goel,

Roles Data curation, Formal analysis, Visualization, Writing – original draft, Writing – review & editing

Affiliation Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India
⨯
Valeria Bellini,

Roles Investigation, Methodology, Visualization

Affiliation Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France
⨯
Karl Harlos,

Roles Data curation, Resources

Affiliation Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
Benoît Laleu,

Roles Funding acquisition, Project administration, Resources

Affiliation Medicines for Malaria Venture (MMV), International Center Cointrin (ICC), Geneva, Switzerland
⨯
Mohamed-Ali Hakimi ,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: mohamed-ali.hakimi@univ-grenoble-alpes.fr (M-AH); amit.icgeb@gmail.com, directornimr@gmail.com, amitpsharma68@gmail.com (AS)

Affiliation Institute for Advanced Biosciences (IAB), Team Host-Pathogen Interactions and Immunity to Infection, INSERM U1209, CNRS UMR5309, Université Grenoble Alpes, Grenoble, France
⨯
Amit Sharma

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: mohamed-ali.hakimi@univ-grenoble-alpes.fr (M-AH); amit.icgeb@gmail.com, directornimr@gmail.com, amitpsharma68@gmail.com (AS)

Affiliations Molecular Medicine–Structural Parasitology Group, International Centre for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India, ICMR-National Institute of Malaria Research, Dwarka, New Delhi, India

https://orcid.org/0000-0002-3305-0034

⨯

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

Manickam Yogavel,
Alexandre Bougdour,
Siddhartha Mishra,
Nipun Malhotra,
Jyoti Chhibber-Goel,
Valeria Bellini,
Karl Harlos,
Benoît Laleu,
Mohamed-Ali Hakimi,
Amit Sharma

Published: February 28, 2023
https://doi.org/10.1371/journal.ppat.1011124

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