Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Michal Kucharski; Grennady Wirjanata; Sourav Nayak; Josephine Boentoro; Jerzy Michal Dziekan; Christina Assisi; Rob W. van der Pluijm; Olivo Miotto; Sachel Mok; Arjen M. Dondorp; Zbynek Bozdech

doi:10.1371/journal.ppat.1011118

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Open Access

Peer-reviewed

Research Article

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Michal Kucharski ,

Contributed equally to this work with: Michal Kucharski, Grennady Wirjanata, Sourav Nayak

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore
⨯
Grennady Wirjanata ,

Contributed equally to this work with: Michal Kucharski, Grennady Wirjanata, Sourav Nayak

Roles Investigation, Methodology, Validation, Writing – original draft

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore
⨯
Sourav Nayak ,

Contributed equally to this work with: Michal Kucharski, Grennady Wirjanata, Sourav Nayak

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore
⨯
Josephine Boentoro,

Roles Investigation, Validation

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore
⨯
Jerzy Michal Dziekan,

Roles Investigation, Methodology, Validation

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore
⨯
Christina Assisi,

Roles Investigation, Methodology, Validation

Affiliation School of Biological Sciences, Nanyang Technological University, Singapore
⨯
Rob W. van der Pluijm,

Roles Conceptualization, Investigation, Resources

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Center of Tropical Medicine and Travel Medicine, Department of Infectious Diseases, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
⨯
Olivo Miotto,

Roles Data curation, Resources

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⨯
Sachel Mok,

Roles Conceptualization, Investigation, Resources, Writing – review & editing

Affiliation Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America
⨯
Arjen M. Dondorp,

Roles Conceptualization, Funding acquisition, Investigation, Resources

Affiliations Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom
⨯
Zbynek Bozdech

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: zbozdech@ntu.edu.sg

Affiliations School of Biological Sciences, Nanyang Technological University, Singapore, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

https://orcid.org/0000-0002-9830-8446

⨯

Short tandem repeat polymorphism in the promoter region of cyclophilin 19B drives its transcriptional upregulation and contributes to drug resistance in the malaria parasite Plasmodium falciparum

Michal Kucharski,
Grennady Wirjanata,
Sourav Nayak,
Josephine Boentoro,
Jerzy Michal Dziekan,
Christina Assisi,
Rob W. van der Pluijm,
Olivo Miotto,
Sachel Mok,
Arjen M. Dondorp

Published: January 25, 2023
https://doi.org/10.1371/journal.ppat.1011118

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