Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses

Pei Li; Jiaxin Hu; Yan Liu; Xiuyuan Ou; Zhixia Mu; Xing Lu; Fuwen Zan; Mengmeng Cao; Lin Tan; Siwen Dong; Yao Zhou; Jian Lu; Qi Jin; Jianwei Wang; Zhiqiang Wu; Yingtao Zhang; Zhaohui Qian

doi:10.1371/journal.ppat.1011116

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Open Access

Peer-reviewed

Research Article

Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses

Pei Li ,

Contributed equally to this work with: Pei Li, Jiaxin Hu, Yan Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jiaxin Hu ,

Contributed equally to this work with: Pei Li, Jiaxin Hu, Yan Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Yan Liu ,

Contributed equally to this work with: Pei Li, Jiaxin Hu, Yan Liu

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Xiuyuan Ou,

Roles Funding acquisition, Investigation, Resources

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Zhixia Mu,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Xing Lu,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Fuwen Zan,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Mengmeng Cao,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Lin Tan,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Siwen Dong,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Yao Zhou,

Roles Investigation

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jian Lu,

Roles Formal analysis, Methodology

Affiliation College of Life Sciences, Peking University, Beijing, China
⨯
Qi Jin,

Roles Project administration, Resources

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Jianwei Wang,

Roles Funding acquisition, Project administration

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Zhiqiang Wu ,

Roles Data curation, Formal analysis, Funding acquisition, Resources

* E-mail: wuzq2009@ipbcams.ac.cn (ZW); zytao@bjmu.edu.cn (YZ); zqian2013@sina.com (ZQ)

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
⨯
Yingtao Zhang ,

Roles Data curation, Formal analysis, Investigation, Methodology, Visualization

* E-mail: wuzq2009@ipbcams.ac.cn (ZW); zytao@bjmu.edu.cn (YZ); zqian2013@sina.com (ZQ)

Affiliation School of Pharmaceutical Sciences, Peking University, Beijing, China
⨯
[ ... ],
Zhaohui Qian

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: wuzq2009@ipbcams.ac.cn (ZW); zytao@bjmu.edu.cn (YZ); zqian2013@sina.com (ZQ)

Affiliation NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

https://orcid.org/0000-0003-4116-4450

⨯
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Effect of polymorphism in Rhinolophus affinis ACE2 on entry of SARS-CoV-2 related bat coronaviruses

Pei Li,
Jiaxin Hu,
Yan Liu,
Xiuyuan Ou,
Zhixia Mu,
Xing Lu,
Fuwen Zan,
Mengmeng Cao,
Lin Tan,
Siwen Dong

Published: January 23, 2023
https://doi.org/10.1371/journal.ppat.1011116

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