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Open Access
Peer-reviewed
Research Article
A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy
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Lu Meng ,
Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao
Roles Data curation, Formal analysis, Investigation, Project administration, Writing – original draft
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Jialu Zha ,
Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao
Roles Data curation, Formal analysis, Investigation
Affiliation CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China
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Bingjie Zhou ,
Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao
Roles Data curation, Formal analysis, Investigation
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Long Cao ,
Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao
Roles Investigation, Resources
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Congli Jiang,
Roles Investigation, Resources
Affiliation Shenzhen Kangtai Biological Products Co., Shenzhen, China
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Yuanfei Zhu,
Roles Investigation
Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Institute of Infectious Diseases ad Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China
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Teng Li,
Roles Investigation
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Lu Lu,
Roles Investigation
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Junqi Zhang,
Roles Resources
Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Institute of Infectious Diseases ad Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China
⨯ - Heng Yang,
- Jian Feng,
- Zhifeng Gu,
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Hong Tang,
Roles Resources
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Lubin Jiang,
Roles Resources
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
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Dianfan Li ,
Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: dianfan.li@sibcb.ac.cn (DL); dlaville@ips.ac.cn (DL); xmzhang@ips.ac.cn (XZ)
Affiliation CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China
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Dimitri Lavillette ,
Roles Conceptualization, Supervision, Writing – review & editing
* E-mail: dianfan.li@sibcb.ac.cn (DL); dlaville@ips.ac.cn (DL); xmzhang@ips.ac.cn (XZ)
Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China
⨯ - [ ... ],
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Xiaoming Zhang
Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
* E-mail: dianfan.li@sibcb.ac.cn (DL); dlaville@ips.ac.cn (DL); xmzhang@ips.ac.cn (XZ)
Affiliations Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China, Nanjing Advanced Academy of Life and Health, Nanjing, China, Shanghai Huashan Institute of Microbes and Infections, Shanghai, China
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A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy
- Lu Meng,
- Jialu Zha,
- Bingjie Zhou,
- Long Cao,
- Congli Jiang,
- Yuanfei Zhu,
- Teng Li,
- Lu Lu,
- Junqi Zhang,
- Heng Yang
![PLOS](/resource/img/logo-plos.png)
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- Published: January 27, 2023
- https://doi.org/10.1371/journal.ppat.1011085