A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy

• Lu Meng ,

  Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao

  Roles Data curation, Formal analysis, Investigation, Project administration, Writing – original draft

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Jialu Zha ,

  Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao

  Roles Data curation, Formal analysis, Investigation

  Affiliation CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China

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• Bingjie Zhou ,

  Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao

  Roles Data curation, Formal analysis, Investigation

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Long Cao ,

  Contributed equally to this work with: Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao

  Roles Investigation, Resources

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Congli Jiang,

  Roles Investigation, Resources

  Affiliation Shenzhen Kangtai Biological Products Co., Shenzhen, China

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• Yuanfei Zhu,

  Roles Investigation

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Institute of Infectious Diseases ad Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China

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• Teng Li,

  Roles Investigation

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Lu Lu,

  Roles Investigation

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Junqi Zhang,

  Roles Resources

  Affiliation Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Institute of Infectious Diseases ad Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China

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• Heng Yang,

  Roles Resources

  Affiliation Suzhou Institute of Systems Medicine, Suzhou, China

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• Jian Feng,

  Roles Resources

  Affiliation Affiliated Hospital of Nantong University, Nantong, China

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• Zhifeng Gu,

  Roles Resources

  Affiliation Affiliated Hospital of Nantong University, Nantong, China

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• Hong Tang,

  Roles Resources

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Lubin Jiang,

  Roles Resources

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

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• Dianfan Li ,

  Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dianfan.li@sibcb.ac.cn (DL); dlaville@ips.ac.cn (DL); xmzhang@ips.ac.cn (XZ)

  Affiliation CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences (CAS), Shanghai, China

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• Dimitri Lavillette ,

  Roles Conceptualization, Supervision, Writing – review & editing

  * E-mail: dianfan.li@sibcb.ac.cn (DL); dlaville@ips.ac.cn (DL); xmzhang@ips.ac.cn (XZ)

  Affiliation Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China

  https://orcid.org/0000-0002-4706-1519

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•  [ ... ],
• Xiaoming Zhang

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: dianfan.li@sibcb.ac.cn (DL); dlaville@ips.ac.cn (DL); xmzhang@ips.ac.cn (XZ)

  Affiliations Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences/University of Chinese Academy of Sciences, Shanghai, China, Nanjing Advanced Academy of Life and Health, Nanjing, China, Shanghai Huashan Institute of Microbes and Infections, Shanghai, China

  https://orcid.org/0000-0001-6732-9132

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