Ubiquitin variants potently inhibit SARS-CoV-2 PLpro and viral replication via a novel site distal to the protease active site

• Vera J. E. van Vliet ,

  Contributed equally to this work with: Vera J. E. van Vliet, Nhan Huynh

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, South Holland, The Netherlands, The Roslin Institute, University of Edinburgh, Midlothian, Scotland, United Kingdom

  https://orcid.org/0000-0003-0401-3055

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• Nhan Huynh ,

  Contributed equally to this work with: Vera J. E. van Vliet, Nhan Huynh

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Judith Palà,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Ankoor Patel,

  Roles Investigation, Writing – original draft

  Affiliation Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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• Alex Singer,

  Roles Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Cole Slater,

  Roles Investigation, Writing – original draft

  Affiliation Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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• Jacky Chung,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Mariska van Huizen,

  Roles Investigation, Methodology

  Affiliation Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, South Holland, The Netherlands

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• Joan Teyra,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Shane Miersch,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Gia-Khanh Luu,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Wei Ye,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Nitin Sharma,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Safder S. Ganaie,

  Roles Investigation

  Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Raquel Russell,

  Roles Investigation

  Affiliation Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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• Chao Chen,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Mindy Maynard,

  Roles Investigation

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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• Gaya K. Amarasinghe,

  Roles Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Brian L. Mark ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: brian.mark@umanitoba.ca (BLM); m.kikkert@lumc.nl (MK); sachdev.sidhu@gmail.com (SSS)

  Affiliation Department of Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada

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• Marjolein Kikkert ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: brian.mark@umanitoba.ca (BLM); m.kikkert@lumc.nl (MK); sachdev.sidhu@gmail.com (SSS)

  Affiliation Department of Medical Microbiology, Leiden University Center of Infectious Diseases (LU-CID), Leiden University Medical Center, Leiden, South Holland, The Netherlands

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•  [ ... ],
• Sachdev S. Sidhu

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: brian.mark@umanitoba.ca (BLM); m.kikkert@lumc.nl (MK); sachdev.sidhu@gmail.com (SSS)

  Affiliations The Anvil Institute, Kitchener, Ontario, Canada, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada

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