A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein

Patrick Bohn; Irke Waßmann; Lisa Wendt; Anne Leske; Thomas Hoenen; Birke A. Tews; Allison Groseth

doi:10.1371/journal.ppat.1011049

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Open Access

Peer-reviewed

Research Article

A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein

Patrick Bohn ,

Contributed equally to this work with: Patrick Bohn, Irke Waßmann

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Irke Waßmann ,

Contributed equally to this work with: Patrick Bohn, Irke Waßmann

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Lisa Wendt,

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Anne Leske,

Roles Investigation, Validation, Writing – review & editing

Affiliation Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Thomas Hoenen,

Roles Formal analysis, Resources, Visualization, Writing – review & editing

Affiliation Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany
⨯
Birke A. Tews,

Roles Formal analysis, Methodology, Resources, Writing – review & editing

Affiliation Institute of Infectology, Friedrich-Loeffler-Institut, Greifswald–Insel Riems, Germany
⨯
Allison Groseth

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: allison.groseth@fli.de

Affiliation Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany

https://orcid.org/0000-0001-9528-5130

⨯

A dsRNA-binding mutant reveals only a minor role of exonuclease activity in interferon antagonism by the arenavirus nucleoprotein

Patrick Bohn,
Irke Waßmann,
Lisa Wendt,
Anne Leske,
Thomas Hoenen,
Birke A. Tews,
Allison Groseth

Published: January 5, 2023
https://doi.org/10.1371/journal.ppat.1011049

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08 Jan 2023
05:50 GMT
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Mutation
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Arenaviruses
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