Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance

Kyle Rapchak; Shiva D. Yagobian; Jackson Moore; Michelle Khattri; Masahiro Shuda

doi:10.1371/journal.ppat.1011039

Loading metrics

Open Access

Peer-reviewed

Research Article

Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance

Kyle Rapchak ,

Contributed equally to this work with: Kyle Rapchak, Shiva D. Yagobian

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Cancer Virology Program, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America
⨯
Shiva D. Yagobian ,

Contributed equally to this work with: Kyle Rapchak, Shiva D. Yagobian

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Cancer Virology Program, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America
⨯
Jackson Moore,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation Cancer Virology Program, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America
⨯
Michelle Khattri,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

Affiliation Cancer Virology Program, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America
⨯
Masahiro Shuda

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: mas253@pitt.edu

Affiliations Cancer Virology Program, University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

https://orcid.org/0000-0003-0595-2572

⨯

Merkel cell polyomavirus small T antigen is a viral transcription activator that is essential for viral genome maintenance

Kyle Rapchak,
Shiva D. Yagobian,
Jackson Moore,
Michelle Khattri,
Masahiro Shuda

Published: December 27, 2022
https://doi.org/10.1371/journal.ppat.1011039

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA replication
Is the Subject Area "DNA replication" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Viral replication
Is the Subject Area "Viral replication" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.
HEK 293 cells
Is the Subject Area "HEK 293 cells" applicable to this article?

Thanks for your feedback.
Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.