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Open Access
Peer-reviewed
Research Article
A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern
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Hilal Ahmad Parray ,
Contributed equally to this work with: Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi
Roles Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Naveen Narayanan ,
Contributed equally to this work with: Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Sonal Garg ,
Contributed equally to this work with: Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi
Roles Data curation, Funding acquisition, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Zaigham Abbas Rizvi ,
Contributed equally to this work with: Hilal Ahmad Parray, Naveen Narayanan, Sonal Garg, Zaigham Abbas Rizvi
Roles Data curation, Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Tripti Shrivastava,
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Sachin Kushwaha,
Roles Conceptualization, Data curation, Formal analysis, Investigation
Affiliation National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
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Janmejay Singh,
Roles Data curation, Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Praveenkumar Murugavelu,
Roles Data curation, Formal analysis
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Anbalagan Anantharaj,
Roles Formal analysis, Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Farha Mehdi,
Roles Data curation, Formal analysis, Investigation
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Nisha Raj,
Roles Data curation, Formal analysis, Investigation
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Shivam Singh,
Roles Data curation, Formal analysis, Investigation
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Jyotsna Dandotiya,
Roles Investigation
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Asha Lukose,
Roles Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Deepti Jamwal,
Roles Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Sandeep Kumar,
Roles Resources
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Adarsh K. Chiranjivi,
Roles Investigation
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Samridhi Dhyani,
Roles Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Nitesh Mishra,
Roles Investigation, Methodology
Affiliation Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
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Sanjeev Kumar,
Roles Resources
Affiliation ICGEB-Emory Vaccine Center, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
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Kamini Jakhar,
Roles Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Sudipta Sonar,
Roles Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Anil Kumar Panchal,
Roles Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Manas Ranjan Tripathy,
Roles Resources
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Shirlie Roy Chowdhury,
Roles Resources
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Shubbir Ahmed,
Roles Resources
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Sweety Samal,
Roles Resources
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Shailendra Mani,
Roles Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Sankar Bhattacharyya,
Roles Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Supratik Das,
Roles Investigation, Methodology
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Subrata Sinha,
Roles Conceptualization, Writing – review & editing
Affiliation Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
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Kalpana Luthra,
Roles Investigation, Methodology, Resources
Affiliation Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
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Gaurav Batra,
Roles Investigation, Methodology, Resources
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Devinder Sehgal,
Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing
Affiliation National Institute of Immunology, Aruna Asaf Ali Marg, New Delhi, India
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Guruprasad R. Medigeshi,
Roles Formal analysis, Investigation, Methodology, Resources, Validation, Writing – review & editing
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Chandresh Sharma ,
Roles Conceptualization, Data curation, Investigation, Methodology, Resources
* E-mail: chandresh@thsti.res.in (CS); aawasthi@thsti.res.in (AA); pgarg@thsti.res.in (PKG); deepak@rcb.res.in (DTN); rajesh@thsti.res.in (RK)
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Amit Awasthi ,
Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Validation, Writing – review & editing
* E-mail: chandresh@thsti.res.in (CS); aawasthi@thsti.res.in (AA); pgarg@thsti.res.in (PKG); deepak@rcb.res.in (DTN); rajesh@thsti.res.in (RK)
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Pramod Kumar Garg ,
Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing – review & editing
* E-mail: chandresh@thsti.res.in (CS); aawasthi@thsti.res.in (AA); pgarg@thsti.res.in (PKG); deepak@rcb.res.in (DTN); rajesh@thsti.res.in (RK)
¶‡ Lead Corresponding authors
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Deepak T. Nair ,
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: chandresh@thsti.res.in (CS); aawasthi@thsti.res.in (AA); pgarg@thsti.res.in (PKG); deepak@rcb.res.in (DTN); rajesh@thsti.res.in (RK)
¶‡ Lead Corresponding authors
Affiliation Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India
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Rajesh Kumar
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: chandresh@thsti.res.in (CS); aawasthi@thsti.res.in (AA); pgarg@thsti.res.in (PKG); deepak@rcb.res.in (DTN); rajesh@thsti.res.in (RK)
Current address: Institute of Advanced Virology (IAV), Trivandrum, Kerala, India
¶‡ Lead Corresponding authors
Affiliation Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad, Haryana, India
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A broadly neutralizing monoclonal antibody overcomes the mutational landscape of emerging SARS-CoV-2 variants of concern
- Hilal Ahmad Parray,
- Naveen Narayanan,
- Sonal Garg,
- Zaigham Abbas Rizvi,
- Tripti Shrivastava,
- Sachin Kushwaha,
- Janmejay Singh,
- Praveenkumar Murugavelu,
- Anbalagan Anantharaj,
- Farha Mehdi
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- Published: December 12, 2022
- https://doi.org/10.1371/journal.ppat.1010994