Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA.1 and BA.2 receptor-binding domains

• Tyler N. Starr ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: tstarr@fredhutch.org (TNS); jbloom@fredhutch.org (JDB)

  ¶‡ These authors share first authorship on this work.

  Affiliations Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biochemistry, University of Utah, Salt Lake City, Utah, United States of America

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• Allison J. Greaney ,

  Roles Conceptualization, Investigation, Methodology, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Medical Scientist Training Program, University of Washington, Seattle, Washington, United States of America

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• Cameron M. Stewart,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• Alexandra C. Walls,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America

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• William W. Hannon,

  Roles Software, Writing – review & editing

  Affiliations Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America

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• David Veesler,

  Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America

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• Jesse D. Bloom

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: tstarr@fredhutch.org (TNS); jbloom@fredhutch.org (JDB)

  Affiliations Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America, Howard Hughes Medical Institute, Seattle, Washington, United States of America

  https://orcid.org/0000-0003-1267-3408

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