Complementary antibody lineages achieve neutralization breadth in an HIV-1 infected elite neutralizer

• Jelle van Schooten,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-5202-355X

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• Anna Schorcht,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Elinaz Farokhi,

  Roles Formal analysis, Investigation

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Jeffrey C. Umotoy,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Hongmei Gao,

  Roles Investigation

  Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

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• Tom L. G. M. van den Kerkhof,

  Roles Investigation

  Affiliations Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands, Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Jessica Dorning,

  Roles Investigation

  Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Tim G. Rijkhold Meesters,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Patricia van der Woude,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Judith A. Burger,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Tom Bijl,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Riham Ghalaiyini,

  Roles Investigation

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• Alba Torrents de la Peña,

  Roles Investigation

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Hannah L. Turner,

  Roles Investigation

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Celia C. Labranche,

  Roles Investigation

  Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

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• Robyn L. Stanfield,

  Roles Investigation

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Devin Sok,

  Roles Investigation

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative, New York, New York, United States of America

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• Hanneke Schuitemaker,

  Roles Resources

  Affiliation Department of Experimental Immunology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

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• David C. Montefiori,

  Roles Funding acquisition, Resources

  Affiliation Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

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• Dennis R. Burton,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, United States of America

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• Gabriel Ozorowski,

  Roles Data curation, Formal analysis, Investigation, Validation

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America

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• Michael S. Seaman,

  Roles Funding acquisition, Resources

  Affiliation Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America

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• Ian A. Wilson,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Rogier W. Sanders,

  Roles Conceptualization, Funding acquisition, Resources, Writing – original draft, Writing – review & editing

  Affiliations Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands, Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

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• Andrew B. Ward,

  Roles Conceptualization, Funding acquisition, Resources

  Affiliations Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America, International AIDS Vaccine Initiative Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development, The Scripps Research Institute, La Jolla, California, United States of America

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•  [ ... ],
• Marit J. van Gils

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: M.J.vangils@amsterdamumc.nl

  Affiliation Department of Medical Microbiology, Amsterdam Infection & Immunity Institute, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam, The Netherlands

  https://orcid.org/0000-0003-3422-8161

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