Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress

Shweta Singh; Gaurav Datta; Shaifali Jain; Vandana Thakur; Priya Arora; Azhar Muneer; Mohd Asad; Shakir Ali; Asif Mohmmed

doi:10.1371/journal.ppat.1010932

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Open Access

Peer-reviewed

Research Article

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress

Shweta Singh ,

Contributed equally to this work with: Shweta Singh, Gaurav Datta

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations International Centre for Genetic Engineering and Biotechnology, New Delhi, India, Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India
⨯
Gaurav Datta ,

Contributed equally to this work with: Shweta Singh, Gaurav Datta

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯
Shaifali Jain,

Roles Data curation, Formal analysis, Methodology

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯
Vandana Thakur,

Roles Data curation, Formal analysis, Methodology

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯
Priya Arora,

Roles Data curation, Formal analysis

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯
Azhar Muneer,

Roles Data curation, Investigation, Methodology

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯
Mohd Asad,

Roles Data curation, Investigation, Methodology

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯
Shakir Ali,

Roles Project administration, Supervision, Writing – review & editing

Affiliation Department of Biochemistry, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India
⨯
Asif Mohmmed

Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: amohd@icgeb.res.in

Affiliation International Centre for Genetic Engineering and Biotechnology, New Delhi, India
⨯

Dual role of an essential HtrA2/Omi protease in the human malaria parasite: Maintenance of mitochondrial homeostasis and induction of apoptosis-like cell death under cellular stress

Shweta Singh,
Gaurav Datta,
Shaifali Jain,
Vandana Thakur,
Priya Arora,
Azhar Muneer,
Mohd Asad,
Shakir Ali,
Asif Mohmmed

Published: October 28, 2022
https://doi.org/10.1371/journal.ppat.1010932

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Mitochondria
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Proteases
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Apoptosis
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Recombinant proteins
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Fluorescence imaging
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Malarial parasites
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Parasitic diseases
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Plasmodium
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