Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages

• John Okombo ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Sachel Mok ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliations Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America, Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

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• Tarrick Qahash,

  Roles Data curation, Methodology

  Affiliations Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Tomas Yeo,

  Roles Data curation, Formal analysis, Methodology, Software

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Jade Bath,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America

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• Lindsey M. Orchard,

  Roles Data curation, Methodology

  Affiliations Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Edward Owens,

  Roles Data curation

  Affiliations Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Imhoi Koo,

  Roles Formal analysis

  Affiliations Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Istvan Albert,

  Roles Software

  Affiliation Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Manuel Llinás,

  Roles Supervision, Writing – review & editing

  Affiliations Department of Biochemistry & Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Huck Center for Malaria Research, The Pennsylvania State University, University Park, Pennsylvania, United States of America, Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania, United States of America

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• David A. Fidock

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft

  * E-mail: df2260@cumc.columbia.edu

  Affiliations Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America, Center for Malaria Therapeutics and Antimicrobial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York, United States of America

  https://orcid.org/0000-0001-6753-8938

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