Cryo-EM reveals the conformational epitope of human monoclonal antibody PAM1.4 broadly reacting with polymorphic malarial protein VAR2CSA

• Sai Sundar Rajan Raghavan,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Robert Dagil,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Mary Lopez-Perez,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Julian Conrad,

  Roles Methodology

  Affiliation Swedish National Cryo-EM Facility, Science for Life Laboratories, Solna, Sweden

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• Maria Rosaria Bassi,

  Roles Resources, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Maria del Pilar Quintana,

  Roles Resources, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Swati Choudhary,

  Roles Formal analysis, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Tobias Gustavsson,

  Roles Formal analysis, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Yong Wang,

  Roles Formal analysis, Writing – review & editing

  Affiliation Joint Research Centre for Engineering Biology, Zhejiang University-University of Edinburgh Institute, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China

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• Pontus Gourdon,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Experimental Medical Science, Lund University, Lund, Sweden

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• Michael Fokuo Ofori,

  Roles Resources, Writing – review & editing

  Affiliation Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

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• Sebastian Boje Christensen,

  Roles Investigation, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Daniel Thomas Remias Minja,

  Roles Resources, Writing – review & editing

  Affiliation National Institute for Medical Research, Tanga Centre, Tanga, Tanzania

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• Christentze Schmiegelow,

  Roles Resources, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Morten Agertoug Nielsen,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Lea Barfod,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Lars Hviid,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Ali Salanti,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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• Thomas Lavstsen ,

  Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: thomasl@sund.ku.dk (TL); kaituo@sund.ku.dk (KW)

  Affiliation Centre for Medical Parasitology at Department for Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, and Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark

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•  [ ... ],
• Kaituo Wang

  Roles Conceptualization, Data curation, Writing – original draft, Writing – review & editing

  * E-mail: thomasl@sund.ku.dk (TL); kaituo@sund.ku.dk (KW)

  Affiliation Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark

  https://orcid.org/0000-0002-5922-7109

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