Glycans are not necessary to maintain the pathobiological features of bovine spongiform encephalopathy

• Alicia Otero ,

  Contributed equally to this work with: Alicia Otero, Tomás Barrio

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, ISS Aragón, Zaragoza, Spain

  ⨯
• Tomás Barrio ,

  Contributed equally to this work with: Alicia Otero, Tomás Barrio

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation UMR INRAE-ENVT 1225 Interactions Hôtes-Agents Pathogènes (IHAP), Institute Nationale de Recherche pour l’Alimentation, l’Agriculture et l’Environnement (INRAE)—École Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse, Toulouse, France

  ⨯
• Hasier Eraña,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Prion Research Lab, Derio, Spain, Atlas Molecular Pharma S. L., Derio, Spain

  ⨯
• Jorge M. Charco,

  Roles Methodology

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Prion Research Lab, Derio, Spain, Atlas Molecular Pharma S. L., Derio, Spain

  ⨯
• Marina Betancor,

  Roles Investigation

  Affiliation Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, ISS Aragón, Zaragoza, Spain

  ⨯
• Carlos M. Díaz-Domínguez,

  Roles Investigation

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Prion Research Lab, Derio, Spain

  ⨯
• Belén Marín,

  Roles Investigation, Methodology

  Affiliation Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, ISS Aragón, Zaragoza, Spain

  ⨯
• Olivier Andréoletti,

  Roles Resources

  Affiliation UMR INRAE-ENVT 1225 Interactions Hôtes-Agents Pathogènes (IHAP), Institute Nationale de Recherche pour l’Alimentation, l’Agriculture et l’Environnement (INRAE)—École Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse, Toulouse, France

  ⨯
• Juan M. Torres,

  Roles Resources

  Affiliation Centro de Investigación en Sanidad Animal, CISA-INIA, Valdeolmos, Madrid, Spain

  ⨯
• Qingzhong Kong,

  Roles Resources

  Affiliation Departments of Pathology and Neurology & National Center for Regenerative Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

  ⨯
• Juan J. Badiola,

  Roles Formal analysis, Funding acquisition, Investigation, Resources, Supervision

  Affiliation Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, ISS Aragón, Zaragoza, Spain

  ⨯
• Rosa Bolea ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – review & editing

  * E-mail: jcastilla@cicbiogune.es (JC); rbolea@unizar.es (RB).

  Affiliation Centro de Encefalopatías y Enfermedades Transmisibles Emergentes, Universidad de Zaragoza, IA2, ISS Aragón, Zaragoza, Spain

  ⨯
• Joaquín Castilla

  Roles Conceptualization, Formal analysis, Methodology, Resources, Supervision, Writing – review & editing

  * E-mail: jcastilla@cicbiogune.es (JC); rbolea@unizar.es (RB).

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Prion Research Lab, Derio, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain, Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain

  https://orcid.org/0000-0002-2216-1361

  ⨯