Immunization with inactivated whole virus particle influenza virus vaccines improves the humoral response landscape in cynomolgus macaques

• Brendon Y. Chua ,

  Contributed equally to this work with: Brendon Y. Chua, Toshiki Sekiya, Marios Koutsakos

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Toshiki Sekiya ,

  Contributed equally to this work with: Brendon Y. Chua, Toshiki Sekiya, Marios Koutsakos

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

  ⨯
• Marios Koutsakos ,

  Contributed equally to this work with: Brendon Y. Chua, Toshiki Sekiya, Marios Koutsakos

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Naoki Nomura,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

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• Louise C. Rowntree,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Thi H. O. Nguyen,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Hayley A. McQuilten,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Marumi Ohno,

  Roles Conceptualization, Formal analysis, Methodology, Writing – review & editing

  Affiliation International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

  ⨯
• Yuki Ohara,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation KM Biologics Co. Ltd., Kumamoto, Japan

  ⨯
• Tomohiro Nishimura,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation KM Biologics Co. Ltd., Kumamoto, Japan

  ⨯
• Masafumi Endo,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation KM Biologics Co. Ltd., Kumamoto, Japan

  ⨯
• Yasushi Itoh,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science, Otsu, Japan

  ⨯
• Jennifer R. Habel,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Kevin J. Selva,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Adam K. Wheatley,

  Roles Formal analysis, Methodology, Resources, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Bruce D. Wines,

  Roles Methodology, Resources, Writing – review & editing

  Affiliations Immune Therapies Group, Burnet Institute, Melbourne, Australia, Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia, Department of Pathology, The University of Melbourne, Parkville, Australia

  ⨯
• P. Mark Hogarth,

  Roles Methodology, Resources, Writing – review & editing

  Affiliations Immune Therapies Group, Burnet Institute, Melbourne, Australia, Department of Immunology and Pathology, Central Clinical School, Monash University, Melbourne, Australia, Department of Pathology, The University of Melbourne, Parkville, Australia

  ⨯
• Stephen J. Kent,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia, Melbourne Sexual Health Centre, Infectious Diseases Department, Alfred Health, Central Clinical School, Monash University, Melbourne, Australia

  ⨯
• Amy W. Chung,

  Roles Formal analysis, Methodology, Resources, Writing – review & editing

  Affiliation Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• David C. Jackson,

  Roles Conceptualization, Writing – review & editing

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Lorena E. Brown,

  Roles Writing – review & editing

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  ⨯
• Masashi Shingai,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

  ⨯
• Katherine Kedzierska ,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kkedz@unimelb.edu.au (KK); kida@vetmed.hokudai.ac.jp (HK)

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, Department of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Australia

  https://orcid.org/0000-0001-6141-335X

  ⨯
•  [ ... ],
• Hiroshi Kida

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: kkedz@unimelb.edu.au (KK); kida@vetmed.hokudai.ac.jp (HK)

  ¶‡ These authors are joint senior authors on this work.

  Affiliations Global Station for Zoonosis Control, Global Institution for Collaborative Research and Education (GI-CoRE) Hokkaido University, Sapporo, Japan, International Institute for Zoonosis Control, Hokkaido University, Sapporo, Japan

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